Genomic and proteomic analysis of mammary tumors arising in transgenic mice

Lu Xie, Baogang J. Xu, Agnieszka E. Gorska, Yu Shyr, Sarah A. Schwartz, Nikki Cheng, Shawn Levy, Brian Bierie, Richard M. Caprioli, Harold L. Moses

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) is the prototype of a large family of signaling molecules. TGF-β signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-β signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.

Original languageEnglish
Pages (from-to)2088-2098
Number of pages11
JournalJournal of Proteome Research
Volume4
Issue number6
DOIs
Publication statusPublished - 2005 Nov

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

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