Genomic and proteomic analysis of mammary tumors arising in transgenic mice

Lu Xie; Baogang J. Xu; Agnieszka E. Gorska; Yu Shyr; Sarah A. Schwartz; Nikki Cheng; Shawn Levy; Brian Bierie; Richard M. Caprioli; Harold L. Moses

doi:10.1021/pr050214l

Genomic and proteomic analysis of mammary tumors arising in transgenic mice

Lu Xie, Baogang J. Xu, Agnieszka E. Gorska, Yu Shyr, Sarah A. Schwartz, Nikki Cheng, Shawn Levy, Brian Bierie, Richard M. Caprioli, Harold L. Moses

Department of Statistics

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10 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) is the prototype of a large family of signaling molecules. TGF-β signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-β signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.

Original language	English
Pages (from-to)	2088-2098
Number of pages	11
Journal	Journal of Proteome Research
Volume	4
Issue number	6
DOIs	https://doi.org/10.1021/pr050214l
Publication status	Published - 2005 Nov

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry

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10.1021/pr050214l

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title = "Genomic and proteomic analysis of mammary tumors arising in transgenic mice",

abstract = "Transforming growth factor-β (TGF-β) is the prototype of a large family of signaling molecules. TGF-β signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-β signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.",

author = "Lu Xie and Xu, {Baogang J.} and Gorska, {Agnieszka E.} and Yu Shyr and Schwartz, {Sarah A.} and Nikki Cheng and Shawn Levy and Brian Bierie and Caprioli, {Richard M.} and Moses, {Harold L.}",

year = "2005",

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journal = "Journal of Proteome Research",

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T1 - Genomic and proteomic analysis of mammary tumors arising in transgenic mice

AU - Xie, Lu

AU - Xu, Baogang J.

AU - Gorska, Agnieszka E.

AU - Shyr, Yu

AU - Schwartz, Sarah A.

AU - Cheng, Nikki

AU - Levy, Shawn

AU - Bierie, Brian

AU - Caprioli, Richard M.

AU - Moses, Harold L.

PY - 2005/11

Y1 - 2005/11

N2 - Transforming growth factor-β (TGF-β) is the prototype of a large family of signaling molecules. TGF-β signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-β signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.

AB - Transforming growth factor-β (TGF-β) is the prototype of a large family of signaling molecules. TGF-β signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-β signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.

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EP - 2098

JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 6

ER -

Genomic and proteomic analysis of mammary tumors arising in transgenic mice

Abstract

All Science Journal Classification (ASJC) codes

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