Genomic organization of the chicken CD8 locus reveals a novel family of immunoreceptor genes

Hung Jiun Liaw, Wei Ru Chen, Yu Chia Huang, Chung Wei Tsai, King Chan Chang, Chia Lam Kuo

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The genomic organization of the chicken CD8α gene was investigated to determine the basis of its polymorphism. Contiguous to the CB8α gene we identified multiple DNA blocks possessing sequences homologous to CB8α. Gene conversions and recombination over evolutionary time among CD8α and these CD8α homologous genes seem to account for the observed polymorphism. Furthermore, these CD8α-like DNAs encode a distinct multigene family of immunoreceptors that have a charged or polar residue in place of the interspecies-conserved CD8α transmembrane proline residue and a short cytoplasmic tail nonhomologous to CD8α. The identification of this novel multigene family with an organization reminiscent of human kiler Ig-like receptors raises compelling questions on their evolutionary relationship among immunoreceptors.

Original languageEnglish
Pages (from-to)3023-3030
Number of pages8
JournalJournal of Immunology
Volume178
Issue number5
DOIs
Publication statusPublished - 2007 Mar 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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