Gestational diabetes and central pontine myelinolysis with quadriplegia

A case report

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Central pontine myelinolysis (CPM) has been reported in women with severe hyperemesis gravidarum-induced hyponatremia followed by rapid correction. Gestational diabetes with adipsia complicated by acute hypernatremia resulting in CPM has never been reported. Here is a case of a disabled female who presented with polydipsia, polyuria, seizures, fetal death in utero, hyperglycemia, and hyper-osmolar hypernatremia on her 31st gestational week. The dead fetus was delivered and the patient's plasma glucose and sodium were later stabilized. When the patient developed quadriplegia and respiratory failure 5 days later, brain magnetic resonance imaging showed central pontine and extra-pontine myelinolysis. Gestational diabetes complicated by hyper-osmolar crisis may cause fetal death and severe neurologic sequela. Early recognition and delivery of the fetus and placenta may improve the electrolyte and fluid imbalance.

Original languageEnglish
Pages (from-to)728-731
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume23
Issue number7
DOIs
Publication statusPublished - 2010 Jan 1

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Central Pontine Myelinolysis
Hypernatremia
Quadriplegia
Fetal Death
Gestational Diabetes
Fetus
Hyperemesis Gravidarum
Polydipsia
Polyuria
Hyponatremia
Respiratory Insufficiency
Hyperglycemia
Placenta
Nervous System
Electrolytes
Cause of Death
Seizures
Sodium
Magnetic Resonance Imaging
Glucose

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

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