TY - JOUR
T1 - Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift
AU - Lin, Cheng Yu
AU - Wu, Jiunn Liang
AU - Shih, Tung Sheng
AU - Tsai, Perng Jy
AU - Sun, Yih Min
AU - Guo, Yueliang Leon
N1 - Funding Information:
The authors thank Miss Wen-Kuei Lin, Miss I.-Hui Lin, Miss Linda J. Chang, and the staffs of the TeamBest Company and the Clinico Company for their assistance in the preparation of this manuscript. This study was supported by grants from the Council of Labor Affairs, the Executive Yuan, and the Tainan Municipal Hospital.
PY - 2009/11
Y1 - 2009/11
N2 - The generation of reactive oxygen species (ROS) is thought to be part of the mechanism underlying noise-induced hearing loss (NIHL). Glutathione is an important cellular antioxidant that limits cell damage by ROS. We aimed to determine the effect of genetic polymorphisms of glutathione S-transferase (GST) T1, GSTM1, and GSTP1, on temporary threshold shift (TTS) in 58 noise-exposed male workers from a steel factory. The pre-shift hearing impairment at high frequency (HF, average of 3, 4, and 6 kHz) was 30.7 dB HL (S.D. = 19.3). The amount of daily noise exposure was 83.0 dBA (S.D. = 5.0). Noise-induced TTS at HF by pure-tone audiometry (PTA) was related to the daily noise exposure (p < 0.05). Based on combinatory analysis, we found that individuals carrying all genotypes with GSTT1 null, GSTM1 null, and GSTP1 Ile105/Ile105 were more susceptible to NIHL. These results suggest that pre-shift hearing impairment and daily noise exposure had impacts on TTS at HF by PTA. In addition, GST genetic polymorphisms may modify the susceptibility to noise-induced TTS.
AB - The generation of reactive oxygen species (ROS) is thought to be part of the mechanism underlying noise-induced hearing loss (NIHL). Glutathione is an important cellular antioxidant that limits cell damage by ROS. We aimed to determine the effect of genetic polymorphisms of glutathione S-transferase (GST) T1, GSTM1, and GSTP1, on temporary threshold shift (TTS) in 58 noise-exposed male workers from a steel factory. The pre-shift hearing impairment at high frequency (HF, average of 3, 4, and 6 kHz) was 30.7 dB HL (S.D. = 19.3). The amount of daily noise exposure was 83.0 dBA (S.D. = 5.0). Noise-induced TTS at HF by pure-tone audiometry (PTA) was related to the daily noise exposure (p < 0.05). Based on combinatory analysis, we found that individuals carrying all genotypes with GSTT1 null, GSTM1 null, and GSTP1 Ile105/Ile105 were more susceptible to NIHL. These results suggest that pre-shift hearing impairment and daily noise exposure had impacts on TTS at HF by PTA. In addition, GST genetic polymorphisms may modify the susceptibility to noise-induced TTS.
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U2 - 10.1016/j.heares.2009.07.008
DO - 10.1016/j.heares.2009.07.008
M3 - Article
C2 - 19643173
AN - SCOPUS:70349853069
VL - 257
SP - 8
EP - 15
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -