TY - JOUR
T1 - Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan
AU - Chang, Tsai Wang
AU - Wang, Shuei Ming
AU - Guo, Yue Liang L.
AU - Tsai, Pei Chien
AU - Huang, Chien Jung
AU - Huang, Wenya
N1 - Funding Information:
This work was supported by grants NSC-92-2314-B-006-148 (W. Huang) and NSC91-3112-B-006-006 (L. L. Guo) from the National Science Council of Taiwan.
PY - 2006/12
Y1 - 2006/12
N2 - In this study, the genetic polymorphisms associated with breast cancer in southern Taiwan were investigated. Two categories of genes were analyzed: (1) BRCA1, BRCA2, and Rad51, the DNA repair factors involved in homologous recombinational repair; and (2) CYP1A1, COMT, GST, and NAT2, the xenobiotic-metabolizing enzymes (XME) involved in estrogen metabolism. We found that the number of deletions and/or mutations in the GST genes was highly correlated with the occurrence of breast cancer. These data suggest that the GST enzymes, which detoxify the catechol estrogen quinones, are important target molecules for screening in populations at high risk of breast cancer.
AB - In this study, the genetic polymorphisms associated with breast cancer in southern Taiwan were investigated. Two categories of genes were analyzed: (1) BRCA1, BRCA2, and Rad51, the DNA repair factors involved in homologous recombinational repair; and (2) CYP1A1, COMT, GST, and NAT2, the xenobiotic-metabolizing enzymes (XME) involved in estrogen metabolism. We found that the number of deletions and/or mutations in the GST genes was highly correlated with the occurrence of breast cancer. These data suggest that the GST enzymes, which detoxify the catechol estrogen quinones, are important target molecules for screening in populations at high risk of breast cancer.
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U2 - 10.1016/j.breast.2006.03.008
DO - 10.1016/j.breast.2006.03.008
M3 - Article
C2 - 16713266
AN - SCOPUS:33751181913
SN - 0960-9776
VL - 15
SP - 754
EP - 761
JO - Breast
JF - Breast
IS - 6
ER -