TY - JOUR
T1 - Grafting of 2-hydroxypropyl-β-cyclodextrin on gum Arabic-modified iron oxide nanoparticles as a magnetic carrier for targeted delivery of hydrophobic anticancer drug
AU - Banerjee, Shashwat S.
AU - Chen, Dong Hwang
PY - 2010/1
Y1 - 2010/1
N2 - A new magnetic nanocarrier for the targeted delivery of hydrophobic drugs was developed by modifying magnetic nanoparticles with gum arabic and grafting with 2-hydroxypropyl-cyclodextrins (HCD) using hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic diameter, and grafting of HCD were characterized. The resultant magnetic nanocarrier exhibited an excellent capability to load all-trans-retinoic acid (ATRA), an anticancer agent. The better biocompatibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the nanosystem an exciting prospect for targeted delivery of hydrophobic drugs.
AB - A new magnetic nanocarrier for the targeted delivery of hydrophobic drugs was developed by modifying magnetic nanoparticles with gum arabic and grafting with 2-hydroxypropyl-cyclodextrins (HCD) using hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic diameter, and grafting of HCD were characterized. The resultant magnetic nanocarrier exhibited an excellent capability to load all-trans-retinoic acid (ATRA), an anticancer agent. The better biocompatibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the nanosystem an exciting prospect for targeted delivery of hydrophobic drugs.
UR - http://www.scopus.com/inward/record.url?scp=73649087984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73649087984&partnerID=8YFLogxK
U2 - 10.1111/j.1744-7402.2008.02332.x
DO - 10.1111/j.1744-7402.2008.02332.x
M3 - Article
AN - SCOPUS:73649087984
SN - 1546-542X
VL - 7
SP - 111
EP - 118
JO - International Journal of Applied Ceramic Technology
JF - International Journal of Applied Ceramic Technology
IS - 1
ER -