Grafting of 2-hydroxypropyl-β-cyclodextrin on gum Arabic-modified iron oxide nanoparticles as a magnetic carrier for targeted delivery of hydrophobic anticancer drug

Shashwat S. Banerjee, Dong Hwang Chen

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

A new magnetic nanocarrier for the targeted delivery of hydrophobic drugs was developed by modifying magnetic nanoparticles with gum arabic and grafting with 2-hydroxypropyl-cyclodextrins (HCD) using hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic diameter, and grafting of HCD were characterized. The resultant magnetic nanocarrier exhibited an excellent capability to load all-trans-retinoic acid (ATRA), an anticancer agent. The better biocompatibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the nanosystem an exciting prospect for targeted delivery of hydrophobic drugs.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalInternational Journal of Applied Ceramic Technology
Volume7
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Condensed Matter Physics
  • Marketing
  • Materials Chemistry

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