Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging

Wen Shuo Kuo, Hua Han Chen, Shih Yao Chen, Chia Yuan Chang, Pei Chi Chen, Yung I. Hou, Yu Ting Shao, Hui Fang Kao, Chih Li Lilian Hsu, Yi Chun Chen, Shean Jen Chen, Shang Rung Wu, Jiu Yao Wang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalBiomaterials
Volume120
DOIs
Publication statusPublished - 2017 Mar 1

Fingerprint

Quantum Dots
Graphite
Photochemotherapy
Graphene
Semiconductor quantum dots
Nitrogen
Photodynamic therapy
Reactive Oxygen Species
Bacteria
Oxygen
Photosensitizing Agents
Photosensitizers
Luminescence
Chemical analysis
Lasers
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Kuo, Wen Shuo ; Chen, Hua Han ; Chen, Shih Yao ; Chang, Chia Yuan ; Chen, Pei Chi ; Hou, Yung I. ; Shao, Yu Ting ; Kao, Hui Fang ; Lilian Hsu, Chih Li ; Chen, Yi Chun ; Chen, Shean Jen ; Wu, Shang Rung ; Wang, Jiu Yao. / Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging. In: Biomaterials. 2017 ; Vol. 120. pp. 185-194.
@article{9e40c8a9b88a4a9f99bc1c8952548c94,
title = "Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging",
abstract = "Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.",
author = "Kuo, {Wen Shuo} and Chen, {Hua Han} and Chen, {Shih Yao} and Chang, {Chia Yuan} and Chen, {Pei Chi} and Hou, {Yung I.} and Shao, {Yu Ting} and Kao, {Hui Fang} and {Lilian Hsu}, {Chih Li} and Chen, {Yi Chun} and Chen, {Shean Jen} and Wu, {Shang Rung} and Wang, {Jiu Yao}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.biomaterials.2016.12.022",
language = "English",
volume = "120",
pages = "185--194",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",

}

Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging. / Kuo, Wen Shuo; Chen, Hua Han; Chen, Shih Yao; Chang, Chia Yuan; Chen, Pei Chi; Hou, Yung I.; Shao, Yu Ting; Kao, Hui Fang; Lilian Hsu, Chih Li; Chen, Yi Chun; Chen, Shean Jen; Wu, Shang Rung; Wang, Jiu Yao.

In: Biomaterials, Vol. 120, 01.03.2017, p. 185-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging

AU - Kuo, Wen Shuo

AU - Chen, Hua Han

AU - Chen, Shih Yao

AU - Chang, Chia Yuan

AU - Chen, Pei Chi

AU - Hou, Yung I.

AU - Shao, Yu Ting

AU - Kao, Hui Fang

AU - Lilian Hsu, Chih Li

AU - Chen, Yi Chun

AU - Chen, Shean Jen

AU - Wu, Shang Rung

AU - Wang, Jiu Yao

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.

AB - Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.

UR - http://www.scopus.com/inward/record.url?scp=85008406244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008406244&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2016.12.022

DO - 10.1016/j.biomaterials.2016.12.022

M3 - Article

C2 - 28063357

AN - SCOPUS:85008406244

VL - 120

SP - 185

EP - 194

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

ER -