Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia

Bao Hong Lee, Chia Chen Lee, Yu Hsiang Cheng, Wen Chang Chang, Wei-Hsuan Hsu, She Ching Wu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hyperglycemia is associated with advanced glycation end products (AGEs). Recently, AGEs were found to cause pancreatic damage, oxidative stress, and hyperglycemia through the AGE receptor. Carboxymethyllysine (CML) is an AGE but whether it induces pancreatic dysfunction remains unclear. Graptopetalum paraguayense, a vegetable consumed in Taiwan, has been used in folk medicine and is an antioxidant that protects against liver damage. We investigated the protective properties of G. paraguayense 95% ethanol extracts (GPEs) against CML-induced pancreatic damage. The results indicated that resveratrol, GPE, and gallic acid (the active compound of GPE) increased insulin synthesis via upregulation of pancreatic peroxisome proliferator activated-receptor-γ (PPARγ) and pancreatic-duodenal homeobox-1 (PDX-1) but inhibited the expression of CML-mediated CCAAT/enhancer binding protein-β (C/EBPβ), a negative regulator of insulin production. Moreover, resveratrol and GPE also strongly activated nuclear factor-erythroid 2-related factor 2 (Nrf2) to attenuate oxidative stress and improve insulin sensitivity in the liver and muscle of CML-injected C57BL/6 mice and resulted in reduced blood glucose levels. Taken together, these findings suggested that GPE and gallic acid could potentially be used as a food supplement to protect against pancreatic damage and the development of diabetes.

Original languageEnglish
Pages (from-to)492-498
Number of pages7
JournalFood and Chemical Toxicology
Volume62
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Graptopetalum paraguayense
resveratrol
hyperglycemia
pancreas
Hyperglycemia
Pancreas
Ethanol
ethanol
Gallic Acid
Oxidative stress
extracts
Insulin
Liver
gallic acid
Oxidative Stress
CCAAT-Enhancer-Binding Proteins
oxidative stress
insulin
Peroxisome Proliferator-Activated Receptors
Advanced Glycosylation End Products

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Lee, Bao Hong ; Lee, Chia Chen ; Cheng, Yu Hsiang ; Chang, Wen Chang ; Hsu, Wei-Hsuan ; Wu, She Ching. / Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia. In: Food and Chemical Toxicology. 2013 ; Vol. 62. pp. 492-498.
@article{0ebbf157e1bb4ba49415ebcfe40972a1,
title = "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia",
abstract = "Hyperglycemia is associated with advanced glycation end products (AGEs). Recently, AGEs were found to cause pancreatic damage, oxidative stress, and hyperglycemia through the AGE receptor. Carboxymethyllysine (CML) is an AGE but whether it induces pancreatic dysfunction remains unclear. Graptopetalum paraguayense, a vegetable consumed in Taiwan, has been used in folk medicine and is an antioxidant that protects against liver damage. We investigated the protective properties of G. paraguayense 95{\%} ethanol extracts (GPEs) against CML-induced pancreatic damage. The results indicated that resveratrol, GPE, and gallic acid (the active compound of GPE) increased insulin synthesis via upregulation of pancreatic peroxisome proliferator activated-receptor-γ (PPARγ) and pancreatic-duodenal homeobox-1 (PDX-1) but inhibited the expression of CML-mediated CCAAT/enhancer binding protein-β (C/EBPβ), a negative regulator of insulin production. Moreover, resveratrol and GPE also strongly activated nuclear factor-erythroid 2-related factor 2 (Nrf2) to attenuate oxidative stress and improve insulin sensitivity in the liver and muscle of CML-injected C57BL/6 mice and resulted in reduced blood glucose levels. Taken together, these findings suggested that GPE and gallic acid could potentially be used as a food supplement to protect against pancreatic damage and the development of diabetes.",
author = "Lee, {Bao Hong} and Lee, {Chia Chen} and Cheng, {Yu Hsiang} and Chang, {Wen Chang} and Wei-Hsuan Hsu and Wu, {She Ching}",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.fct.2013.09.005",
language = "English",
volume = "62",
pages = "492--498",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",

}

Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia. / Lee, Bao Hong; Lee, Chia Chen; Cheng, Yu Hsiang; Chang, Wen Chang; Hsu, Wei-Hsuan; Wu, She Ching.

In: Food and Chemical Toxicology, Vol. 62, 01.01.2013, p. 492-498.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia

AU - Lee, Bao Hong

AU - Lee, Chia Chen

AU - Cheng, Yu Hsiang

AU - Chang, Wen Chang

AU - Hsu, Wei-Hsuan

AU - Wu, She Ching

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Hyperglycemia is associated with advanced glycation end products (AGEs). Recently, AGEs were found to cause pancreatic damage, oxidative stress, and hyperglycemia through the AGE receptor. Carboxymethyllysine (CML) is an AGE but whether it induces pancreatic dysfunction remains unclear. Graptopetalum paraguayense, a vegetable consumed in Taiwan, has been used in folk medicine and is an antioxidant that protects against liver damage. We investigated the protective properties of G. paraguayense 95% ethanol extracts (GPEs) against CML-induced pancreatic damage. The results indicated that resveratrol, GPE, and gallic acid (the active compound of GPE) increased insulin synthesis via upregulation of pancreatic peroxisome proliferator activated-receptor-γ (PPARγ) and pancreatic-duodenal homeobox-1 (PDX-1) but inhibited the expression of CML-mediated CCAAT/enhancer binding protein-β (C/EBPβ), a negative regulator of insulin production. Moreover, resveratrol and GPE also strongly activated nuclear factor-erythroid 2-related factor 2 (Nrf2) to attenuate oxidative stress and improve insulin sensitivity in the liver and muscle of CML-injected C57BL/6 mice and resulted in reduced blood glucose levels. Taken together, these findings suggested that GPE and gallic acid could potentially be used as a food supplement to protect against pancreatic damage and the development of diabetes.

AB - Hyperglycemia is associated with advanced glycation end products (AGEs). Recently, AGEs were found to cause pancreatic damage, oxidative stress, and hyperglycemia through the AGE receptor. Carboxymethyllysine (CML) is an AGE but whether it induces pancreatic dysfunction remains unclear. Graptopetalum paraguayense, a vegetable consumed in Taiwan, has been used in folk medicine and is an antioxidant that protects against liver damage. We investigated the protective properties of G. paraguayense 95% ethanol extracts (GPEs) against CML-induced pancreatic damage. The results indicated that resveratrol, GPE, and gallic acid (the active compound of GPE) increased insulin synthesis via upregulation of pancreatic peroxisome proliferator activated-receptor-γ (PPARγ) and pancreatic-duodenal homeobox-1 (PDX-1) but inhibited the expression of CML-mediated CCAAT/enhancer binding protein-β (C/EBPβ), a negative regulator of insulin production. Moreover, resveratrol and GPE also strongly activated nuclear factor-erythroid 2-related factor 2 (Nrf2) to attenuate oxidative stress and improve insulin sensitivity in the liver and muscle of CML-injected C57BL/6 mice and resulted in reduced blood glucose levels. Taken together, these findings suggested that GPE and gallic acid could potentially be used as a food supplement to protect against pancreatic damage and the development of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84884944623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884944623&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2013.09.005

DO - 10.1016/j.fct.2013.09.005

M3 - Article

VL - 62

SP - 492

EP - 498

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -