Greater availability of dopamine transporters in patients with major depression - A dual-isotope SPECT study

Yen-Kuang Yang, Tzung Lieh Yeh, Wei-Jen Yao, I-Hui Lee, Po-See Chen, Nan-Tsing Chiu, Ru-Band Lu

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In order to explore the neuropathology of the pre- and post-synaptic dopamine neurons of patients with major depression, we examined striatal D2/D3 receptor uptake and dopamine transporter (DAT) availability simultaneously in drug-free depressed patients using a dual-isotope single photon emission computed tomography (SPECT) imaging technique. Ten unmedicated patients with unmediated depression and ten healthy controls were recruited. The striatal dopamine D2/D3 receptor availability was measured using SPECT and [123I] IBZM, while DAT was measured using SPECT and [99mTc] TRODAT-1. The symptom changes of the drug-free patients were reassessed after a 4-week antidepressant treatment. DAT binding in the patient group were significantly higher than in control group. That was not the case, however, for striatal D2/D3 receptor availability. Pre-treatment striatal DAT availability correlated only marginally with changes in the Hamilton Depression Rating Scale after 4 weeks of treatment. Central dopamine functions may be altered in patients with major depression, particularly in the pre-synaptic sites.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalPsychiatry Research - Neuroimaging
Volume162
Issue number3
DOIs
Publication statusPublished - 2008 Apr 15

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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