Grouper Mx confers resistance to nodavirus and interacts with coat protein

Young Mao Chen, Yung Lin Su, Pei Shiuan Shie, Shao Ling Huang, Huey Lang Yang, Tzong Yueh Chen

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Over-expression of grouper Mx negatively regulated nodavirus activity through direct interaction, likely via the binding and perturbation of the intracellular localization of nodavirus coat protein. Deletion analysis of grouper Mx indicated that the coat protein binds to the effector domain of Mx. The presence of grouper Mx in a poly [I:C] interferon system inhibited nodavirus infection, demonstrating that grouper Mx over-expression has an inhibitory effect on both coat protein and RNA-dependent RNA polymerase of nodavirus antigens, which results in reduced viral yields. We conclude that grouper Mx has a key role in cellular resistance to nodavirus infection.

Original languageEnglish
Pages (from-to)825-836
Number of pages12
JournalDevelopmental and Comparative Immunology
Volume32
Issue number7
DOIs
Publication statusPublished - 2008 Jan 1

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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