Gut microbiota and pediatric obesity/non-alcoholic fatty liver disease

Yao Jong Yang, Yen Hsuan Ni

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Huge amount microorganisms resides in human intestine, and many contribute to the maturation and homeostasis of immune system. The diversity of gut ecology are affected by the gestational age, delivery type, feeding sources, and antibiotics use in neonates. Recent studies pointed out that disturbance of gut microbiota, so called dysbiosis, could result in several pediatric diseases including obesity, non-alcoholic fatty liver disease (NAFLD), metabolic syndromes, allergic diseases, and inflammatory bowel diseases. However, there are no single species can be proven to play a key factor in pediatric obesity and NAFLD at present. Various probiotics may confer benefit to these gut microbiota-related pediatric diseases. The clinical application is still limited. This review article aimed to elucidate evidently the relationship between gut microbiota and pediatric obesity/NAFLD and to discuss the potential probiotics use in pediatric obesity and NAFLD.

Original languageEnglish
Pages (from-to)S55-S61
JournalJournal of the Formosan Medical Association
Volume118
DOIs
Publication statusPublished - 2019 Mar

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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