TY - JOUR
T1 - H-InvDB in 2013
T2 - An omics study platform for human functional gene and transcript discovery
AU - Takeda, Jun Ichi
AU - Yamasaki, Chisato
AU - Murakami, Katsuhiko
AU - Nagai, Yoko
AU - Sera, Miho
AU - Hara, Yuichiro
AU - Obi, Nobuo
AU - Habara, Takuya
AU - Gojobori, Takashi
AU - Imanishi, Tadashi
PY - 2013/1/1
Y1 - 2013/1/1
N2 - H-InvDB (http://www.h-invitational.jp/) is a comprehensive human gene database started in 2004. In the latest version, H-InvDB 8.0, a total of 244 709 human complementary DNA was mapped onto the hg19 reference genome and 43829 gene loci, including nonprotein-coding ones, were identified. Of these loci, 35631 were identified as potential protein-coding genes, and 22898 of these were identical to known genes. In our analysis, 19309 annotated genes were specific to H-InvDB and not found in RefSeq and Ensembl. In fact, 233 genes of the 19 309 turned out to have protein functions in this version of H-InvDB; they were annotated as unknown protein functions in the previous version. Furthermore, 11 genes were identified as known Mendelian disorder genes. It is advantageous that many biologically functional genes are hidden in the H-InvDB unique genes. As large-scale proteomic projects have been conducted to elucidate the functions of all human proteins, we have enhanced the proteomic information with an advanced protein view and new subdatabase of protein complexes (Protein Complex Database with quality index). We propose that H-InvDB is an important resource for finding novel candidate targets for medical care and drug development.
AB - H-InvDB (http://www.h-invitational.jp/) is a comprehensive human gene database started in 2004. In the latest version, H-InvDB 8.0, a total of 244 709 human complementary DNA was mapped onto the hg19 reference genome and 43829 gene loci, including nonprotein-coding ones, were identified. Of these loci, 35631 were identified as potential protein-coding genes, and 22898 of these were identical to known genes. In our analysis, 19309 annotated genes were specific to H-InvDB and not found in RefSeq and Ensembl. In fact, 233 genes of the 19 309 turned out to have protein functions in this version of H-InvDB; they were annotated as unknown protein functions in the previous version. Furthermore, 11 genes were identified as known Mendelian disorder genes. It is advantageous that many biologically functional genes are hidden in the H-InvDB unique genes. As large-scale proteomic projects have been conducted to elucidate the functions of all human proteins, we have enhanced the proteomic information with an advanced protein view and new subdatabase of protein complexes (Protein Complex Database with quality index). We propose that H-InvDB is an important resource for finding novel candidate targets for medical care and drug development.
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U2 - 10.1093/nar/gks1245
DO - 10.1093/nar/gks1245
M3 - Article
C2 - 23197657
AN - SCOPUS:84876572333
SN - 0305-1048
VL - 41
SP - D915-D919
JO - Nucleic acids research
JF - Nucleic acids research
IS - D1
ER -