TY - JOUR
T1 - H. pylori eradication does not reduce gastric cancer incidence in a high-risk area of China
AU - Sheu, Bor Shyang
AU - Lin, Xi Zhang
N1 - Funding Information:
Sources of funding: This study was funded by the Research Grant Council, Hong Kong Special Administration Region, the Peptic Ulcer Research Fund, the Simon K Y Lee Gastroenterology Research Fund of the University of Hong Kong and the Henry Fok Foundation, Hong Kong.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004/8
Y1 - 2004/8
N2 - Question. Does treating H. Pylori reduce the incidence of gastric cancer? Study. Randomised placebo-controlled trial. Main results. At 7.5 years, incidence of gastric cancer was not significantly different between groups (treatment: 0.86%, n= 7; placebo: 1.35%, n =11; p =0.33). In people without precancerous lesions at baseline, risk of gastric cancer was significantly lower for treatment compared with placebo (incidence of gastric cancer: treatment n =0; placebo n =6; p =0.02) but there was no difference among people with precancerous lesions (n =7 and 5, respectively). Smoking (hazard ratio [HR] 6.2, 95% CI 2.3 to 16.5) and older age (HR per 1 year 1.10, 95% CI 1.05 to 1.15) were independent predictors of gastric cancer risk. Authors' conclusions. Incidence of gastric cancer was similar between H. pylori eradication and placebo groups over 7.5 years of follow-up. However, it was significantly reduced in a subgroup of people without precancerous lesions at baseline.
AB - Question. Does treating H. Pylori reduce the incidence of gastric cancer? Study. Randomised placebo-controlled trial. Main results. At 7.5 years, incidence of gastric cancer was not significantly different between groups (treatment: 0.86%, n= 7; placebo: 1.35%, n =11; p =0.33). In people without precancerous lesions at baseline, risk of gastric cancer was significantly lower for treatment compared with placebo (incidence of gastric cancer: treatment n =0; placebo n =6; p =0.02) but there was no difference among people with precancerous lesions (n =7 and 5, respectively). Smoking (hazard ratio [HR] 6.2, 95% CI 2.3 to 16.5) and older age (HR per 1 year 1.10, 95% CI 1.05 to 1.15) were independent predictors of gastric cancer risk. Authors' conclusions. Incidence of gastric cancer was similar between H. pylori eradication and placebo groups over 7.5 years of follow-up. However, it was significantly reduced in a subgroup of people without precancerous lesions at baseline.
UR - http://www.scopus.com/inward/record.url?scp=13244252231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13244252231&partnerID=8YFLogxK
U2 - 10.1016/j.ehbc.2004.05.005
DO - 10.1016/j.ehbc.2004.05.005
M3 - Comment/debate
AN - SCOPUS:13244252231
SN - 1462-9410
VL - 8
SP - 218
EP - 220
JO - Evidence-Based Healthcare
JF - Evidence-Based Healthcare
IS - 4
ER -
