Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study

Nan Yu Cheng, Shih Yu Tzeng, Ming Chein Fang, Chun Yen Kuo, Wen Hsien Lu, Chin Chieh Yang, Sheng Hao Tseng

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The prevalence rate of neonatal jaundice can reach 80%, of which 5% may develop dangerous hemolytic jaundice. The blood test for obtaining bilirubin and hemoglobin concentration is the gold standard for diagnosing hemolytic jaundice; however, frequently drawing blood from jaundice neonates for the screening purpose is not practical. We have developed a handheld diffuse reflectance spectroscopy system to noninvasively determine the bilirubin and hemoglobin levels in neonates. Our study showed that the correlation coefficients were 0.95 and 0.80 for bilirubin and hemoglobin between the results from the blood tests and our handheld system, respectively. This handheld system could be an effective tool for screening hemolytic jaundice.

Original languageEnglish
Pages (from-to)467-476
Number of pages10
JournalBiomedical Optics Express
Volume14
Issue number1
DOIs
Publication statusPublished - 2023 Jan 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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