Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study

Nan Yu Cheng; Shih Yu Tzeng; Ming Chein Fang; Chun Yen Kuo; Wen Hsien Lu; Chin Chieh Yang; Sheng Hao Tseng

doi:10.1364/BOE.475531

Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study

Nan Yu Cheng, Shih Yu Tzeng, Ming Chein Fang, Chun Yen Kuo, Wen Hsien Lu, Chin Chieh Yang, Sheng Hao Tseng

Department of Photonics

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The prevalence rate of neonatal jaundice can reach 80%, of which 5% may develop dangerous hemolytic jaundice. The blood test for obtaining bilirubin and hemoglobin concentration is the gold standard for diagnosing hemolytic jaundice; however, frequently drawing blood from jaundice neonates for the screening purpose is not practical. We have developed a handheld diffuse reflectance spectroscopy system to noninvasively determine the bilirubin and hemoglobin levels in neonates. Our study showed that the correlation coefficients were 0.95 and 0.80 for bilirubin and hemoglobin between the results from the blood tests and our handheld system, respectively. This handheld system could be an effective tool for screening hemolytic jaundice.

Original language	English
Pages (from-to)	467-476
Number of pages	10
Journal	Biomedical Optics Express
Volume	14
Issue number	1
DOIs	https://doi.org/10.1364/BOE.475531
Publication status	Published - 2023 Jan 1

All Science Journal Classification (ASJC) codes

Biotechnology
Atomic and Molecular Physics, and Optics

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10.1364/BOE.475531

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@article{188e8fa6e8ed4d5ea8a7a51c0cd968d5,

title = "Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study",

abstract = "The prevalence rate of neonatal jaundice can reach 80%, of which 5% may develop dangerous hemolytic jaundice. The blood test for obtaining bilirubin and hemoglobin concentration is the gold standard for diagnosing hemolytic jaundice; however, frequently drawing blood from jaundice neonates for the screening purpose is not practical. We have developed a handheld diffuse reflectance spectroscopy system to noninvasively determine the bilirubin and hemoglobin levels in neonates. Our study showed that the correlation coefficients were 0.95 and 0.80 for bilirubin and hemoglobin between the results from the blood tests and our handheld system, respectively. This handheld system could be an effective tool for screening hemolytic jaundice.",

author = "Cheng, {Nan Yu} and Tzeng, {Shih Yu} and Fang, {Ming Chein} and Kuo, {Chun Yen} and Lu, {Wen Hsien} and Yang, {Chin Chieh} and Tseng, {Sheng Hao}",

note = "Funding Information: Ministry of Science and Technology, Taiwan (MOST 109-2811-E-006-503-MY2, MOST-107-2221-E-006-148, MOST-108-2221-E-006-207-MY3). We would like to show our gratitude to Dr. Jenn-Tzong Chang, Dr Yen-Ting Lin, and all nurses in Sick Baby Room in Kaohsiung Veterans General Hospital for assisting the research. Publisher Copyright: {\textcopyright} 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.",

year = "2023",

month = jan,

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doi = "10.1364/BOE.475531",

language = "English",

volume = "14",

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journal = "Biomedical Optics Express",

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T1 - Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations

T2 - a pilot study

AU - Cheng, Nan Yu

AU - Tzeng, Shih Yu

AU - Fang, Ming Chein

AU - Kuo, Chun Yen

AU - Lu, Wen Hsien

AU - Yang, Chin Chieh

AU - Tseng, Sheng Hao

N1 - Funding Information: Ministry of Science and Technology, Taiwan (MOST 109-2811-E-006-503-MY2, MOST-107-2221-E-006-148, MOST-108-2221-E-006-207-MY3). We would like to show our gratitude to Dr. Jenn-Tzong Chang, Dr Yen-Ting Lin, and all nurses in Sick Baby Room in Kaohsiung Veterans General Hospital for assisting the research. Publisher Copyright: © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - The prevalence rate of neonatal jaundice can reach 80%, of which 5% may develop dangerous hemolytic jaundice. The blood test for obtaining bilirubin and hemoglobin concentration is the gold standard for diagnosing hemolytic jaundice; however, frequently drawing blood from jaundice neonates for the screening purpose is not practical. We have developed a handheld diffuse reflectance spectroscopy system to noninvasively determine the bilirubin and hemoglobin levels in neonates. Our study showed that the correlation coefficients were 0.95 and 0.80 for bilirubin and hemoglobin between the results from the blood tests and our handheld system, respectively. This handheld system could be an effective tool for screening hemolytic jaundice.

AB - The prevalence rate of neonatal jaundice can reach 80%, of which 5% may develop dangerous hemolytic jaundice. The blood test for obtaining bilirubin and hemoglobin concentration is the gold standard for diagnosing hemolytic jaundice; however, frequently drawing blood from jaundice neonates for the screening purpose is not practical. We have developed a handheld diffuse reflectance spectroscopy system to noninvasively determine the bilirubin and hemoglobin levels in neonates. Our study showed that the correlation coefficients were 0.95 and 0.80 for bilirubin and hemoglobin between the results from the blood tests and our handheld system, respectively. This handheld system could be an effective tool for screening hemolytic jaundice.

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JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 1

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Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study

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