In wheel manufacturing processes, stickers or labels are always pasted on products as decoration or identification. The labeling process is completed traditionally by workers, which could lead to increased cost and poor efficiency. In this paper, the design and hardware realization of wheel-shape objects labeling and quality inspection cyber-physical system is presented. The proposed cyber-physical system consists of three systems (1) the label operation system, (2) the wheel operation platform, and (3) the vision-based feedback and quality inspection system. The human-completed labeling process is expected to be replaced by integrating the aforementioned systems. The designed cyber-physical system is applied to the labeling process of bicycle rim to validate the design and present the results.