HCV co-infection among people living with HIV Is associated with Higher fracture risk

Iqbal Pramukti, Hsiao Ying Liu, Chang Chun Chen, Yen Chin Chen, Chun Yin Yeh, Susan Fetzer, Kusman Ibrahim, Ta Wei Tai, Wen Chien Ko, Nai Ying Ko

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The purpose of this study was to predict the 10-year risk of fracture among people living with HIV (PLWH) using FRAX™, and to determine the risk factors related to a high probability of fractures. Methodology: This study consisted of 288 subjects aged 40 years and above. The ten-year probability of major osteoporotic fractures (MOF) and hip fractures was assessed using the FRAX™ algorithm with bone mineral density (BMD) data. A logistic regression was used to determine risk factors related to a high probability of major osteoporotic fracture and hip fracture. Results: The median 10-year probability of fracture was 3.7% (IQR 2.2–6.2) for MOF and 0.8% (IQR 0.3–2.5) for hip fractures. In addition to old age, previous fracture history, and low T-scores, HCV co-infection was associated with a higher risk of hip fractures in PLWH (AOR: 4.3, 95% CI: 1.29–14.33). Old age and low T-scores were also associated with a high probability of MOF. Conclusions: HCV co-infection among PLWH is associated with a higher risk of hip fracture. Sustained efforts in terms of pharmacologic and non-pharmacologic interventions in PLWH are necessary to prevent osteoporotic fractures, especially in those with HCV co-infections.

Original languageEnglish
Pages (from-to)1724-1728
Number of pages5
JournalJournal of Infection and Public Health
Volume13
Issue number11
DOIs
Publication statusPublished - 2020 Nov

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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