TY - JOUR
T1 - Health-related quality of life among patients with moderate-to-severe plaque psoriasis in Taiwan
AU - Tsai, Tsen Fang
AU - Ho, Ji Chen
AU - Chen, Yi Ju
AU - Hsiao, Pa Fan
AU - Lee, Woan Ruoh
AU - Chi, Ching Chi
AU - Lan, Cheng Che
AU - Hui, Rosaline Chung Yee
AU - Lin, Yang Chih
AU - Yang, Kuo Chia
AU - Wong, Tak Wah
AU - Sheu, Hamm Ming
AU - Hsu, Hsiu Cheng
AU - Chu, Gong Yau
AU - Huang, Yu Huei
N1 - Funding Information:
The authors thank Tim T.H. Wang, PhD, former Janssen Taiwan employee for his contribution in the data management and analysis and the study operation; and Catherine Ni, of Janssen Global Clinical Operation, Central Trial Coordination Team MAO Asia Pacific for her contributions to the study operation and quality management. This study was supported by funding from 1) Janssen Taiwan Medical Affairs Writing and editorial support was provided by ApotheCom (Singapore), and was funded by 2) Janssen Taiwan, Johnson & Johnson Ltd . Statistical analysis was provided by QPS Qualitix, and funded by 3) Janssen Taiwan Medical Affairs .
Funding Information:
The authors thank Tim T.H. Wang, PhD, former Janssen Taiwan employee for his contribution in the data management and analysis and the study operation; and Catherine Ni, of Janssen Global Clinical Operation, Central Trial Coordination Team MAO Asia Pacific for her contributions to the study operation and quality management. This study was supported by funding from 1) Janssen Taiwan Medical Affairs Writing and editorial support was provided by ApotheCom (Singapore), and was funded by 2) Janssen Taiwan, Johnson & Johnson Ltd. Statistical analysis was provided by QPS Qualitix, and funded by 3) Janssen Taiwan Medical Affairs.
Publisher Copyright:
© 2018
PY - 2018/12
Y1 - 2018/12
N2 - Background/Objectives: Plaque psoriasis is a debilitating condition that significantly affects patient well-being. Limited data are available regarding the effect of psoriasis and treatment on health-related quality of life (HRQoL) and work ability among Taiwanese patients. To document and compare HRQoL, treatment satisfaction, and work disability among Taiwanese patients with current and past moderate-to-severe plaque psoriasis. Methods: This was a multicenter, non-interventional, cross-sectional study of adult patients with moderate-to-severe plaque psoriasis. During a single clinic visit, each patient was assessed for body surface area (BSA) involvement, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), Euro Quality of Life-5 Dimensions (EQ-5D), 10-level satisfaction scale for psoriasis treatment, and Working Productivity and Activity Impairment (WPAI). Multivariate regression was used to identify factors associated with HRQoL and work disability. Results: A total of 305 patients were included within the analysis. The mean PASI score was 11.83, and the mean BSA involvement was 20.90%. The mean EQ-5D score was 65.68 and the mean DLQI score was 12.55. Fewer than half of patients (45.68%) indicated they were satisfied with the standard therapy they were currently receiving. Among employed patients, the mean reduction in on-the-job effectiveness was 32.09% and the mean reduction in overall productivity was 33.48%. The regression analysis indicated that patients with more severe psoriasis defined by PASI scores show a greater impact in quality of life and impairment in work disability; and that patients who were satisfied with current standard treatment had a better quality of life. Conclusion: The effect of psoriasis on HRQoL among patients with psoriasis in Taiwan is substantial, with fewer than half of patients reporting satisfaction with therapeutic options.
AB - Background/Objectives: Plaque psoriasis is a debilitating condition that significantly affects patient well-being. Limited data are available regarding the effect of psoriasis and treatment on health-related quality of life (HRQoL) and work ability among Taiwanese patients. To document and compare HRQoL, treatment satisfaction, and work disability among Taiwanese patients with current and past moderate-to-severe plaque psoriasis. Methods: This was a multicenter, non-interventional, cross-sectional study of adult patients with moderate-to-severe plaque psoriasis. During a single clinic visit, each patient was assessed for body surface area (BSA) involvement, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), Euro Quality of Life-5 Dimensions (EQ-5D), 10-level satisfaction scale for psoriasis treatment, and Working Productivity and Activity Impairment (WPAI). Multivariate regression was used to identify factors associated with HRQoL and work disability. Results: A total of 305 patients were included within the analysis. The mean PASI score was 11.83, and the mean BSA involvement was 20.90%. The mean EQ-5D score was 65.68 and the mean DLQI score was 12.55. Fewer than half of patients (45.68%) indicated they were satisfied with the standard therapy they were currently receiving. Among employed patients, the mean reduction in on-the-job effectiveness was 32.09% and the mean reduction in overall productivity was 33.48%. The regression analysis indicated that patients with more severe psoriasis defined by PASI scores show a greater impact in quality of life and impairment in work disability; and that patients who were satisfied with current standard treatment had a better quality of life. Conclusion: The effect of psoriasis on HRQoL among patients with psoriasis in Taiwan is substantial, with fewer than half of patients reporting satisfaction with therapeutic options.
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U2 - 10.1016/j.dsi.2018.06.006
DO - 10.1016/j.dsi.2018.06.006
M3 - Article
AN - SCOPUS:85052287706
SN - 1027-8117
VL - 36
SP - 190
EP - 195
JO - Dermatologica Sinica
JF - Dermatologica Sinica
IS - 4
ER -