Health risk assessment by measuring plasma malondialdehyde (MDA), urinary 8-hydroxydeoxyguanosine (8-OH-dG) and DNA strand breakage following metal exposure in foundry workers

Hung Hsin Liu, Ming Hsiu Lin, Po Ching Liu, Chia I. Chan, Hsiu Ling Chen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Silica particles and metals are important occupational hazards in foundry workers, and exposure may result in DNA damage and lipid peroxidation through oxidative stress. This study aimed to compare oxidative damage by measuring the levels of plasma malondialdehyde (MDA), urinary 8-hydroxydeoxyguanosine (8-OH-dG) and DNA strand breakage in workers at two foundry plants (exposure group) and in town hall employees (control group) in central Taiwan. Air samples for metals analysis in the workplace were also collected to assess the health risk to foundry workers. Significantly higher MDA levels (4.28 μM versus 1.64 μM), DNA strand breakage (6.63 versus 1.22), and 8-OH-dG levels (5.00 μg/g creatinine versus 1.84 μg/g creatinine) were found in exposure group compared with the control group. Higher levels of these parameters were also found in workers involved in manufacturing than in workers involved in administration. Higher air respirable dust concentrations were found in manufacturing departments (0.99 mg/m3) than in administrative departments (0.34 mg/m3). The health risk assessment on metals exposure showed that the cancer risk for Cd, Cr and Ni were all above 1 × 10-6. Future studies are necessary to determine whether metals exposure can contribute to oxidative damage in foundry workers.

Original languageEnglish
Pages (from-to)699-704
Number of pages6
JournalJournal of Hazardous Materials
Volume170
Issue number2-3
DOIs
Publication statusPublished - 2009 Oct 30

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

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