@article{031100670e814a009365d6e42619b3a6,
title = "Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience",
abstract = "Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-α1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GaIT-KO pigs increased graft survival over previous studies.",
author = "Kenji Kuwaki and Tseng, {Yau Lin} and Dor, {Frank J.M.F.} and Akira Shimizu and Houser, {Stuart L.} and Sanderson, {Todd M.} and Lancos, {Courtney J.} and Prabharasuth, {Derek D.} and Jane Cheng and Kathleen Moran and Yosuke Hisashi and Nicolas Mueller and Kazuhiko Yamada and Greenstein, {Julia L.} and Hawley, {Robert J.} and Clive Patience and Michel Awwad and Fishman, {Jay A.} and Robson, {Simon C.} and Schuurman, {Henk Jan} and Sachs, {David H.} and Cooper, {David K.C.}",
note = "Funding Information: We thank L. Buhler and C. Knosalla for their comments on this manuscript, and R. Colvin for comments on the histopathology. We also thank W. Schuler and his colleagues at the Novartis Institutes for Biomedical Research for making ABI793 available to us, and P. Albientz, R. Buergi and F. Legay for developing the assay to measure levels of ABI793. Y-L Tseng is a recipient of a grant from the National Cheng Kung University Hospital, Taiwan. F.J.M.F. Dor is a recipient of grants from the Ter Meulen Fund from the Royal Netherlands Academy of Arts and Sciences, the Prof. Micha{\"e}l-van Vloten Fund, and the Netherland-America Foundation. D.H. Sachs, J.A. Fishman, S.C. Robson, K. Yamada and D.K.C. Cooper were consultants to Immerge BioTherapeutics, Inc. This work was supported in part by US National Institutes of Health Program Project 1PO1A45897 and by a Sponsored Research Agreement between the Massachusetts General Hospital and Immerge BioTherapeutics, Inc.",
year = "2005",
month = jan,
doi = "10.1038/nm1171",
language = "English",
volume = "11",
pages = "29--31",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "1",
}