Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience

Kenji Kuwaki, Yau Lin Tseng, Frank J.M.F. Dor, Akira Shimizu, Stuart L. Houser, Todd M. Sanderson, Courtney J. Lancos, Derek D. Prabharasuth, Jane Cheng, Kathleen Moran, Yosuke Hisashi, Nicolas Mueller, Kazuhiko Yamada, Julia L. Greenstein, Robert J. Hawley, Clive Patience, Michel Awwad, Jay A. Fishman, Simon C. Robson, Henk Jan SchuurmanDavid H. Sachs, David K.C. Cooper

Research output: Contribution to journalArticlepeer-review

526 Citations (Scopus)

Abstract

Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-α1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GaIT-KO pigs increased graft survival over previous studies.

Original languageEnglish
Pages (from-to)29-31
Number of pages3
JournalNature Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 2005 Jan

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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