Heavy Metal Components in Blood and Urinary Stones of Urolithiasis Patients

Yunhe Yen, Borshuh Cheng, Changchung Chan, Chiwei Lin, Hsiu-Ling Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Lifestyle, food intake, and exposure to chemicals are potential risk factors for the development of calcium urolithiasis. Pb, Cd, and Hg have been proved to cause renal illness, and urinary tract stones might be caused by exposure to metals. Therefore, this study aimed to measure the concentration of metals in urinary tract stones and blood simultaneously in urolithiasis patients. Moreover, we intended to determine whether urinary tract stones can be regarded as a biomarker of exposure or an effect marker in a population with environmental exposure to metals. Thirty-five urolithiasis patients (case) and 34 healthy inhabitants (control) were recruited in this study. The contents of Pb, Cd, Cr, Cu, Ni, As, Zn, and Hg were determined in urinary stones and blood in the case and control groups. The most abundant metals were Zn and Cu in blood and Zn and Ni in urinary stones. Significantly higher levels of Zn, Ni, and As were found in calcium phosphate stones than in calcium oxalate or uric acid stones. The majority of metals were not present at consistent levels in both blood and urinary stones, except for Zn. Urinary stones might be explained as providing another metabolic pathway for metal contamination. Moreover, as the metals with the highest content in urinary stones were Ni and Zn, and Ni content was very much higher than in other countries, contamination by Ni should be further taken into consideration if there is any serious contamination in Taiwan.

Original languageEnglish
Pages (from-to)266-274
Number of pages9
JournalBiological Trace Element Research
Volume185
Issue number2
DOIs
Publication statusPublished - 2018 Oct 1

Fingerprint

Urinary Calculi
Urolithiasis
Heavy Metals
Blood
Metals
Contamination
Calcium Oxalate
Chemical potential
Biomarkers
Uric Acid
Environmental Exposure
Metabolic Networks and Pathways
Taiwan
Life Style
Calcium
Eating
Kidney
Control Groups

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry
  • Biochemistry, medical

Cite this

Yen, Yunhe ; Cheng, Borshuh ; Chan, Changchung ; Lin, Chiwei ; Chen, Hsiu-Ling. / Heavy Metal Components in Blood and Urinary Stones of Urolithiasis Patients. In: Biological Trace Element Research. 2018 ; Vol. 185, No. 2. pp. 266-274.
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Heavy Metal Components in Blood and Urinary Stones of Urolithiasis Patients. / Yen, Yunhe; Cheng, Borshuh; Chan, Changchung; Lin, Chiwei; Chen, Hsiu-Ling.

In: Biological Trace Element Research, Vol. 185, No. 2, 01.10.2018, p. 266-274.

Research output: Contribution to journalArticle

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