TY - JOUR
T1 - Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative Behcet's disease patients
AU - Chiang, Chun Pin
AU - Wu, Yu Hsueh
AU - Chang, Julia Yu Fong
AU - Wang, Yi Ping
AU - Wu, Yang Che
AU - Sun, Andy
N1 - Funding Information:
This study was supported by the grants (No. 102-2314-B-002-125-MY3 and No. 105-2314-B-002-075-MY2 ) of Ministry of Science and Technology, ROC .
Funding Information:
This study was supported by the grants (No. 102-2314-B-002-125-MY3 and No. 105-2314-B-002-075-MY2) of Ministry of Science and Technology, ROC.
Publisher Copyright:
© 2018
PY - 2019/1
Y1 - 2019/1
N2 - Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs − RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs − RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs − RAS/BD patients. Moreover, Abs − RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs − RAS/BD patients.
AB - Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs − RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs − RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs − RAS/BD patients. Moreover, Abs − RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs − RAS/BD patients.
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U2 - 10.1016/j.jfma.2018.05.017
DO - 10.1016/j.jfma.2018.05.017
M3 - Article
C2 - 29898820
AN - SCOPUS:85048513387
SN - 0929-6646
VL - 118
SP - 347
EP - 353
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 1P2
ER -