Hemodynamic, biological, and right ventricular functional changes following intraatrial shunt repair in patients with flow-induced pulmonary hypertension

Chin-Hsin Hsu, Jun-Neng Roan, Jieh-Neng Wang, Chien Chi Huang, Chao Jung Shih, Jyh Hong Chen, Jing-Ming Wu, Chen Fuh Lam

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling. We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction. Design: This prospective cohort study included 37 patients who were admitted for an occluder implantation. Blood samples were collected before and after the procedure. We determined the number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations. Daily performance and cardiothoracic ratio were reevaluated later. Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic peptide levels. The cardiothoracic ratio and daily performance status also improved. The number of endothelial progenitor cell outgrowth colony-forming units significantly increased and was positively correlated with daily performance. In patients with enhanced colony formation, Hsp27 levels were significantly increased. Conclusions: The implantation of an occluder successfully improved hemodynamic, right ventricular, and daily performance. Qualitative enhancement of colony formation for endothelial progenitor cells was also noted and positively correlated with daily performance. Closure of defects may serve as a valid, reliable model to obtain a deeper understanding of the modulation of endothelial progenitor cell activity and its relationship with pulmonary hypertension prognosis.

Original languageEnglish
Pages (from-to)533-539
Number of pages7
JournalCongenital Heart Disease
Volume12
Issue number4
DOIs
Publication statusPublished - 2017 Jul 1

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Pulmonary Hypertension
Hemodynamics
Atrial Heart Septal Defects
Brain Natriuretic Peptide
Cohort Studies
Stem Cells
Endothelial Progenitor Cells
Prospective Studies
Pressure
Lung
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Hemodynamic, biological, and right ventricular functional changes following intraatrial shunt repair in patients with flow-induced pulmonary hypertension",
abstract = "Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling. We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction. Design: This prospective cohort study included 37 patients who were admitted for an occluder implantation. Blood samples were collected before and after the procedure. We determined the number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations. Daily performance and cardiothoracic ratio were reevaluated later. Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic peptide levels. The cardiothoracic ratio and daily performance status also improved. The number of endothelial progenitor cell outgrowth colony-forming units significantly increased and was positively correlated with daily performance. In patients with enhanced colony formation, Hsp27 levels were significantly increased. Conclusions: The implantation of an occluder successfully improved hemodynamic, right ventricular, and daily performance. Qualitative enhancement of colony formation for endothelial progenitor cells was also noted and positively correlated with daily performance. Closure of defects may serve as a valid, reliable model to obtain a deeper understanding of the modulation of endothelial progenitor cell activity and its relationship with pulmonary hypertension prognosis.",
author = "Chin-Hsin Hsu and Jun-Neng Roan and Jieh-Neng Wang and Huang, {Chien Chi} and Shih, {Chao Jung} and Chen, {Jyh Hong} and Jing-Ming Wu and Lam, {Chen Fuh}",
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Hemodynamic, biological, and right ventricular functional changes following intraatrial shunt repair in patients with flow-induced pulmonary hypertension. / Hsu, Chin-Hsin; Roan, Jun-Neng; Wang, Jieh-Neng; Huang, Chien Chi; Shih, Chao Jung; Chen, Jyh Hong; Wu, Jing-Ming; Lam, Chen Fuh.

In: Congenital Heart Disease, Vol. 12, No. 4, 01.07.2017, p. 533-539.

Research output: Contribution to journalArticle

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AU - Hsu, Chin-Hsin

AU - Roan, Jun-Neng

AU - Wang, Jieh-Neng

AU - Huang, Chien Chi

AU - Shih, Chao Jung

AU - Chen, Jyh Hong

AU - Wu, Jing-Ming

AU - Lam, Chen Fuh

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Y1 - 2017/7/1

N2 - Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling. We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction. Design: This prospective cohort study included 37 patients who were admitted for an occluder implantation. Blood samples were collected before and after the procedure. We determined the number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations. Daily performance and cardiothoracic ratio were reevaluated later. Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic peptide levels. The cardiothoracic ratio and daily performance status also improved. The number of endothelial progenitor cell outgrowth colony-forming units significantly increased and was positively correlated with daily performance. In patients with enhanced colony formation, Hsp27 levels were significantly increased. Conclusions: The implantation of an occluder successfully improved hemodynamic, right ventricular, and daily performance. Qualitative enhancement of colony formation for endothelial progenitor cells was also noted and positively correlated with daily performance. Closure of defects may serve as a valid, reliable model to obtain a deeper understanding of the modulation of endothelial progenitor cell activity and its relationship with pulmonary hypertension prognosis.

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