Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry

Mikhail Lara, Chia-Yuan Chen, Philip Mannor, Onur Dur, Prahlad G. Menon, Ajit P. Yoganathan, Kerem Pekkan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Despite rapid advancements in the patient-specific hemodynamic analysis of systemic arterial anatomies, limited attention has been given to the characterization of major venous flow components, such as the hepatic venous confluence. A detailed investigation of hepatic flow structures is essential to better understand the origin of characteristic abnormal venous flow patterns observed in patients with cardiovascular venous disease. The present study incorporates transparent rapid-prototype replicas of two pediatric hepatic venous confluence anatomies and two-component particle image velocimetry to investigate the primary flow structures influencing the inferior vena cava outflow. Novel jet flow regimes are reported at physiologically relevant mean venous conditions. The sensitivity of fluid unsteadiness and hydraulic resistance to multiple-inlet flow regimes is documented. Pressure drop measurements, jet flow characterization, and blood damage assessments are also performed. Results indicate that the orientation of the inlets significantly influences the major unsteady flow structures and power loss characteristics of this complex venous flow junction. Compared to out-of-plane arranged inlet vessel configuration, the internal flow field observed in planar inlet configurations was less sensitive to the venous inlet flow split. Under pathological flow conditions, the effective pressure drop increased as much as 77% compared to the healthy flow state. Experimental flow field results presented here can serve as a benchmark case for the surgical optimization of complex anatomical confluences including visceral hemodynamics as well as for the experimental validation of high-resolution computational fluid dynamics solvers applied to anatomical confluences with multiple inlets and outlets.

Original languageEnglish
Pages (from-to)2398-2416
Number of pages19
JournalAnnals of biomedical engineering
Volume39
Issue number9
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Hemodynamics
Flow structure
Velocity measurement
Inlet flow
Pressure drop
Flow fields
Intake systems
Pediatrics
Unsteady flow
Flow patterns
Computational fluid dynamics
Blood
Hydraulics
Fluids

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Lara, Mikhail ; Chen, Chia-Yuan ; Mannor, Philip ; Dur, Onur ; Menon, Prahlad G. ; Yoganathan, Ajit P. ; Pekkan, Kerem. / Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry. In: Annals of biomedical engineering. 2011 ; Vol. 39, No. 9. pp. 2398-2416.
@article{8fc89433ef984126827d7f7bcce85ac3,
title = "Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry",
abstract = "Despite rapid advancements in the patient-specific hemodynamic analysis of systemic arterial anatomies, limited attention has been given to the characterization of major venous flow components, such as the hepatic venous confluence. A detailed investigation of hepatic flow structures is essential to better understand the origin of characteristic abnormal venous flow patterns observed in patients with cardiovascular venous disease. The present study incorporates transparent rapid-prototype replicas of two pediatric hepatic venous confluence anatomies and two-component particle image velocimetry to investigate the primary flow structures influencing the inferior vena cava outflow. Novel jet flow regimes are reported at physiologically relevant mean venous conditions. The sensitivity of fluid unsteadiness and hydraulic resistance to multiple-inlet flow regimes is documented. Pressure drop measurements, jet flow characterization, and blood damage assessments are also performed. Results indicate that the orientation of the inlets significantly influences the major unsteady flow structures and power loss characteristics of this complex venous flow junction. Compared to out-of-plane arranged inlet vessel configuration, the internal flow field observed in planar inlet configurations was less sensitive to the venous inlet flow split. Under pathological flow conditions, the effective pressure drop increased as much as 77{\%} compared to the healthy flow state. Experimental flow field results presented here can serve as a benchmark case for the surgical optimization of complex anatomical confluences including visceral hemodynamics as well as for the experimental validation of high-resolution computational fluid dynamics solvers applied to anatomical confluences with multiple inlets and outlets.",
author = "Mikhail Lara and Chia-Yuan Chen and Philip Mannor and Onur Dur and Menon, {Prahlad G.} and Yoganathan, {Ajit P.} and Kerem Pekkan",
year = "2011",
month = "9",
day = "1",
doi = "10.1007/s10439-011-0326-1",
language = "English",
volume = "39",
pages = "2398--2416",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "9",

}

Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry. / Lara, Mikhail; Chen, Chia-Yuan; Mannor, Philip; Dur, Onur; Menon, Prahlad G.; Yoganathan, Ajit P.; Pekkan, Kerem.

In: Annals of biomedical engineering, Vol. 39, No. 9, 01.09.2011, p. 2398-2416.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry

AU - Lara, Mikhail

AU - Chen, Chia-Yuan

AU - Mannor, Philip

AU - Dur, Onur

AU - Menon, Prahlad G.

AU - Yoganathan, Ajit P.

AU - Pekkan, Kerem

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Despite rapid advancements in the patient-specific hemodynamic analysis of systemic arterial anatomies, limited attention has been given to the characterization of major venous flow components, such as the hepatic venous confluence. A detailed investigation of hepatic flow structures is essential to better understand the origin of characteristic abnormal venous flow patterns observed in patients with cardiovascular venous disease. The present study incorporates transparent rapid-prototype replicas of two pediatric hepatic venous confluence anatomies and two-component particle image velocimetry to investigate the primary flow structures influencing the inferior vena cava outflow. Novel jet flow regimes are reported at physiologically relevant mean venous conditions. The sensitivity of fluid unsteadiness and hydraulic resistance to multiple-inlet flow regimes is documented. Pressure drop measurements, jet flow characterization, and blood damage assessments are also performed. Results indicate that the orientation of the inlets significantly influences the major unsteady flow structures and power loss characteristics of this complex venous flow junction. Compared to out-of-plane arranged inlet vessel configuration, the internal flow field observed in planar inlet configurations was less sensitive to the venous inlet flow split. Under pathological flow conditions, the effective pressure drop increased as much as 77% compared to the healthy flow state. Experimental flow field results presented here can serve as a benchmark case for the surgical optimization of complex anatomical confluences including visceral hemodynamics as well as for the experimental validation of high-resolution computational fluid dynamics solvers applied to anatomical confluences with multiple inlets and outlets.

AB - Despite rapid advancements in the patient-specific hemodynamic analysis of systemic arterial anatomies, limited attention has been given to the characterization of major venous flow components, such as the hepatic venous confluence. A detailed investigation of hepatic flow structures is essential to better understand the origin of characteristic abnormal venous flow patterns observed in patients with cardiovascular venous disease. The present study incorporates transparent rapid-prototype replicas of two pediatric hepatic venous confluence anatomies and two-component particle image velocimetry to investigate the primary flow structures influencing the inferior vena cava outflow. Novel jet flow regimes are reported at physiologically relevant mean venous conditions. The sensitivity of fluid unsteadiness and hydraulic resistance to multiple-inlet flow regimes is documented. Pressure drop measurements, jet flow characterization, and blood damage assessments are also performed. Results indicate that the orientation of the inlets significantly influences the major unsteady flow structures and power loss characteristics of this complex venous flow junction. Compared to out-of-plane arranged inlet vessel configuration, the internal flow field observed in planar inlet configurations was less sensitive to the venous inlet flow split. Under pathological flow conditions, the effective pressure drop increased as much as 77% compared to the healthy flow state. Experimental flow field results presented here can serve as a benchmark case for the surgical optimization of complex anatomical confluences including visceral hemodynamics as well as for the experimental validation of high-resolution computational fluid dynamics solvers applied to anatomical confluences with multiple inlets and outlets.

UR - http://www.scopus.com/inward/record.url?scp=80051552982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051552982&partnerID=8YFLogxK

U2 - 10.1007/s10439-011-0326-1

DO - 10.1007/s10439-011-0326-1

M3 - Article

VL - 39

SP - 2398

EP - 2416

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 9

ER -