Hemostasis Plug for an Electromagnetic Thermotherapy and Its Application for Liver Laceration

Chung Hsien Liu, Sheng Chieh Huang, Ying-Jui Chao, Xi-Zhang Lin, Gwo Bin Lee

Research output: Contribution to journalArticle

Abstract

Accident-induced liver trauma is a significant human health concern, as this organ is readily injured during periods at which the abdominal region is compromised. In this work, electromagnetic thermotherapy was successfully developed and employed in vitro and in vivo to treat livers that had been lacerated. Briefly, a new hemostasis plug was integrated with an electromagnetic thermotherapy system (ETS) to perform surgery on lacerated livers. The high-frequency, alternating electromagnetic field (EMF) was generated by the ETS and was shown to induce a pre-set temperature increase within the hemostasis plug embedded in the target tissue. In order to prevent overheating and maintain a constant hemostasis temperature, a temperature feedback control system was utilized. The effect of the intensity of the EMF on the heating capacity of the ETS-hemostasis system was first explored. Furthermore, the relationship between the coagulation zone and operating temperature were investigated in vitro. By utilizing the temperature feedback control system, the hemostasis plug could be heated to a specific temperature for efficient hemostasis. With this approach, the optimal treatment temperature and time were investigated for liver laceration. Lacerated livers from New Zealand white rabbits were successfully treated with the hemostasis plug and ETS within a short period of time. When compared with the traditional perihepatic packing approach, the volume of blood loss from liver laceration surgeries treated by ETS has been dramatically reduced by 83%, suggesting a high therapeutic potential for this system.

Original languageEnglish
Pages (from-to)1310-1320
Number of pages11
JournalAnnals of biomedical engineering
Volume44
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

Liver
Temperature control
Electromagnetic fields
Surgery
Feedback control
Temperature
Control systems
Coagulation
Accidents
Blood
Health
Tissue
Heating

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

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title = "Hemostasis Plug for an Electromagnetic Thermotherapy and Its Application for Liver Laceration",
abstract = "Accident-induced liver trauma is a significant human health concern, as this organ is readily injured during periods at which the abdominal region is compromised. In this work, electromagnetic thermotherapy was successfully developed and employed in vitro and in vivo to treat livers that had been lacerated. Briefly, a new hemostasis plug was integrated with an electromagnetic thermotherapy system (ETS) to perform surgery on lacerated livers. The high-frequency, alternating electromagnetic field (EMF) was generated by the ETS and was shown to induce a pre-set temperature increase within the hemostasis plug embedded in the target tissue. In order to prevent overheating and maintain a constant hemostasis temperature, a temperature feedback control system was utilized. The effect of the intensity of the EMF on the heating capacity of the ETS-hemostasis system was first explored. Furthermore, the relationship between the coagulation zone and operating temperature were investigated in vitro. By utilizing the temperature feedback control system, the hemostasis plug could be heated to a specific temperature for efficient hemostasis. With this approach, the optimal treatment temperature and time were investigated for liver laceration. Lacerated livers from New Zealand white rabbits were successfully treated with the hemostasis plug and ETS within a short period of time. When compared with the traditional perihepatic packing approach, the volume of blood loss from liver laceration surgeries treated by ETS has been dramatically reduced by 83{\%}, suggesting a high therapeutic potential for this system.",
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Hemostasis Plug for an Electromagnetic Thermotherapy and Its Application for Liver Laceration. / Liu, Chung Hsien; Huang, Sheng Chieh; Chao, Ying-Jui; Lin, Xi-Zhang; Lee, Gwo Bin.

In: Annals of biomedical engineering, Vol. 44, No. 4, 01.04.2016, p. 1310-1320.

Research output: Contribution to journalArticle

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