Hepatitis B virus transmission and hepatocarcinogenesis: A 9 year retrospective cohort of 13 676 relatives with hepatocellular carcinoma

Chien Hung Chen, Yang Yuan Chen, Gran Hum Chen, Sien Sing Yang, Huang Shang Tang, Hsien Hong Lin, Deng Yn Lin, Sing Kai Lo, Jeng Ming Du, Ting Tsung Chang, Shinn Cherng Chen, Li Ying Liao, Chung Huang Kuo, Kwo Chuan Lin, Dar In Tai, Chi Sin Changchien, Wen Yu Chang, Jin Chuan Sheu, Ding Shinn Chen, Yun Fan LiawJuei Low Sung

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Abstract

Background/Aims Familial clustering of hepatitis B virus (HBV) infection is related to perinatal transmission, and is the main cause of familial-type hepatocellular carcinoma (HCC). The route of HBV transmission differs between the children and siblings of patients with HCC. This study examined the differences in HBV carrier rates and HCC-related mortality between two generations in HCC families. Methods From 1992 to 1997, relatives of individuals with HCC were screened prospectively with ultrasonography, alpha-fetoprotein, liver biochemistry tests and viral markers. Total HCC-related deaths during a 9-year period were compared between the generations of index patients and their children. Results The study included a total of 13676 relatives in two generations. More HCC-related deaths occurred in the index patient generation than in the child generation. Furthermore, children of female index patients had higher rates of liver cancer related mortality than children of male index patients. The same was true when the analysis was limited to male HBV carriers. The prevalence of HBsAg in the offspring of HBsAg positive mothers was 66% in the child generation and 72% in the index patient generation. These high prevalences indicated high maternal HBV replication status. Conclusions Perinatal transmission and maternal viral load are important risk factors in hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalJournal of Hepatology
Volume40
Issue number4
DOIs
Publication statusPublished - 2004 Apr

All Science Journal Classification (ASJC) codes

  • Hepatology

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    Chen, C. H., Chen, Y. Y., Chen, G. H., Yang, S. S., Tang, H. S., Lin, H. H., Lin, D. Y., Lo, S. K., Du, J. M., Chang, T. T., Chen, S. C., Liao, L. Y., Kuo, C. H., Lin, K. C., Tai, D. I., Changchien, C. S., Chang, W. Y., Sheu, J. C., Chen, D. S., ... Sung, J. L. (2004). Hepatitis B virus transmission and hepatocarcinogenesis: A 9 year retrospective cohort of 13 676 relatives with hepatocellular carcinoma. Journal of Hepatology, 40(4), 653-659. https://doi.org/10.1016/j.jhep.2003.12.002