Hepatoid Adenocarcinoma of the Lung: An Unusual Subtype of Lung Cancer

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Hepatoid adenocarcinoma of the lung (HAL) is a rare lung cancer typically defined as an alpha-fetoprotein (AFP)producing primary cancer with mimic histopathologic features of hepatocellular carcinoma. We present a case of HAL in a 48-year-old male patient with a history of smoking and alcohol consumption. He complained of chronic productive cough with blood-tinged sputum, right upper chest wall pain, and weight loss. Chest CT showed a large, necrotic tumor in right upper lung with amorphous calcification and mass effect on mediastinal structures. His serum AFP levels were highly elevated (34,700 mg/mL). After CT-guided biopsy, the diagnosis of HAL was confirmed by the histopathologic identification of hepatoid cells with positive expression of AFP.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalChinese Journal of Radiology
Publication statusPublished - 2017 Mar 1

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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