@article{33d4203c23614237b885c1ef5329cc16,
title = "Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells",
abstract = "Pancreatic cancer is refractory and is characterized by extensively surrounding and intratumor fibrotic reactions that are contributed by activated pancreatic stellate cells (PSCs). Herein, we show that CCAAT/enhancer-binding protein δ (CEBPD) responds to transforming growth factor-β1 (TGF-β1) through reciprocal loop regulation and that activated hypoxia inducible factor-1α (HIF-1α) further contributes to the upregulation of the hepatoma-derived growth factor (HDGF) gene. Secreted HDGF contributes to the antiapoptosis of PSCs and consequently leads to the synthesis and deposition of extracellular matrix proteins for stabilizing PSC/pancreatic cancer cell (PCC) tumor foci. This result agrees with the observation that severe stromal growth positively correlated with stromal HDGF and CEBPD expression in pancreatic cancer specimens. Collectively, the identification of the TGF-β1-activated CEBPD/HIF-1α/HDGF axis provides new insights into novel discoveries of HDGF in the antiapoptosis and profibrosis of PSCs and the outgrowth of PCCs.",
author = "Chen, {Yi Ting} and Chen, {Feng Wei} and Chang, {Tsung Hao} and Wang, {Tso Wen} and Hsu, {Teng Po} and Chi, {Jhih Ying} and Hsiao, {Yu Wei} and Li, {Chien Feng} and Wang, {Ju Ming}",
note = "Funding Information: This work was financially supported by the National Science Council Taiwan Grants ( NHRI-EX106-10422BI from the National Health Research Institute and MOST 106-2320-B-006-063-MY3 from the Ministry of Science and Technology) and Chi Mei Medical Center Research Taiwan Grant #10501 . Funding Information: This work was financially supported by the National Science Council Taiwan Grants (NHRI-EX106-10422BI from the National Health Research Institute and MOST 106-2320-B-006-063-MY3 from the Ministry of Science and Technology) and Chi Mei Medical Center Research Taiwan Grant #10501. We are grateful for the experimental material providing from Dr. Kelvin K.-C. Tsai (National Health Research Institutes, Taiwan), Dr. Yan-Shen Shan (National Cheng Kung University Hospital, Taiwan), Professor Shaw-Jenq Tsai (National Cheng Kung University, Taiwan), and Professor Ming-Hong Tai (National Sun Yat-sen University, Taiwan). Dr. Tzu-Ju Chen (Chi Mei Medical Center, Taiwan) assisted the pathological re-evaluation of immunohistochemistry analysis. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",
year = "2019",
month = aug,
day = "10",
doi = "10.1016/j.canlet.2019.05.001",
language = "English",
volume = "457",
pages = "180--190",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
}