Hepatoprotective principles and other chemical constituents from the mycelium of Phellinus linteus

Shiow Chyn Huang, Pei Wen Wang, Ping Chung Kuo, Hsin Yi Hung, Tai Long Pan

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D–N (4–14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

Original languageEnglish
Article number1705
JournalMolecules
Volume23
Issue number7
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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