Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Shiow Chyn Huang, Pei Wen Wang, Ping-Chung Kuo, Hsin-Yi Hung, Tai Long Pan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

Original languageEnglish
JournalMolecules (Basel, Switzerland)
Volume23
Issue number7
DOIs
Publication statusPublished - 2018 Jul 12

Fingerprint

fibrosis
Mycelium
rats
Rats
Norisoprenoids
Dimethylnitrosamine
Fibrosis
food
Hepatic Stellate Cells
drugs
Liver
Derivatives
Wistar Rats
cells
Pharmaceutical Preparations
Food
Phellinus linteus extract

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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abstract = "In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.",
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Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus. / Huang, Shiow Chyn; Wang, Pei Wen; Kuo, Ping-Chung; Hung, Hsin-Yi; Pan, Tai Long.

In: Molecules (Basel, Switzerland), Vol. 23, No. 7, 12.07.2018.

Research output: Contribution to journalArticle

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AU - Huang, Shiow Chyn

AU - Wang, Pei Wen

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AU - Hung, Hsin-Yi

AU - Pan, Tai Long

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