Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Shiow Chyn Huang, Pei Wen Wang, Ping Chung Kuo, Hsin Yi Hung, Tai Long Pan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

Original languageEnglish
JournalMolecules (Basel, Switzerland)
Volume23
Issue number7
DOIs
Publication statusPublished - 2018 Jul 12

Fingerprint

fibrosis
Mycelium
rats
Rats
Norisoprenoids
Dimethylnitrosamine
Fibrosis
food
Hepatic Stellate Cells
drugs
Liver
Derivatives
Wistar Rats
cells
Pharmaceutical Preparations
Food
Phellinus linteus extract

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

@article{1ff6c957a18241769eb1fc239aeb7c46,
title = "Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus",
abstract = "In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.",
author = "Huang, {Shiow Chyn} and Wang, {Pei Wen} and Kuo, {Ping Chung} and Hung, {Hsin Yi} and Pan, {Tai Long}",
year = "2018",
month = "7",
day = "12",
doi = "10.3390/molecules23071705",
language = "English",
volume = "23",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus. / Huang, Shiow Chyn; Wang, Pei Wen; Kuo, Ping Chung; Hung, Hsin Yi; Pan, Tai Long.

In: Molecules (Basel, Switzerland), Vol. 23, No. 7, 12.07.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

AU - Huang, Shiow Chyn

AU - Wang, Pei Wen

AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Pan, Tai Long

PY - 2018/7/12

Y1 - 2018/7/12

N2 - In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

AB - In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

UR - http://www.scopus.com/inward/record.url?scp=85055596280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055596280&partnerID=8YFLogxK

U2 - 10.3390/molecules23071705

DO - 10.3390/molecules23071705

M3 - Article

C2 - 30002357

AN - SCOPUS:85055596280

VL - 23

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 7

ER -