HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy

Ann Ann Ding, Ying Yi Chen, Ren Chris Churng-Wang, Pai Chi Li, Dar-Bin Shieh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Recent studies reported gold nano rod (AuNRs) exhibit surface plasmonic resonance frequency (SPR) proportional to their aspect ratio. The interaction of AuNRs with electromagnetic radiation corresponding to their SPR could generate local regional heat. With precise control of the aspect ratio, AuNR could interact with near-infrared (NIR) laser light in the biological optical window that best penetrate human tissues to optimize hyperthermia therapy [1]. We exploit AuNRs to conjugate HER-2 antibodies specific for targeting tumor cells. HER-2 was reported to be associated with disease prognosis and clinical theray [2] and was reported to be over-expressed in many types of cancer. In this study, AuNRs was found to present high bio-compatibility and hemo-compatibility. In vitro laser induced hyperthermia study revealed a selective damage of OECM-1 cancer cells targeted by the AuNR probe. We discovered only the use of AuNR combined correct laser wavelength corresponding to SPR of the AuNR could induce effective hyperthermia therapy. In vivo model using tumor bearing SCID mice, an increase in tumor local temperature and improved therapeutic results were discovered in the AuNRs-HER2 treatment group compared to that of AuNRs alone. In conclusion, HER-2 antibodies conjugated AuNR combined NIR laser could be a potent modality in cancer targeting therapy that could minimize side effects attribute to the nanoscale precision of high temperature delivery. Besides, AuNRs showed a tunable SPR within NIR range could be applied for multiplex photo-thermal effect and combined multiple target photo-acoustic molecular imaging for combined diagnosis and therapy in a single platform.

Original languageEnglish
Title of host publication2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
Pages882-885
Number of pages4
DOIs
Publication statusPublished - 2008 Nov 10
Event2008 8th IEEE Conference on Nanotechnology, IEEE-NANO - Arlington, TX, United States
Duration: 2008 Aug 182008 Aug 21

Publication series

Name2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

Other

Other2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
CountryUnited States
CityArlington, TX
Period08-08-1808-08-21

Fingerprint

Antibodies
Hyperthermia therapy
Gold
Tumors
Infrared lasers
Aspect ratio
Bearings (structural)
Cells
Acoustic imaging
Molecular imaging
Lasers
Biocompatibility
Electromagnetic waves
Thermal effects
Tissue
Infrared radiation
Wavelength
Temperature

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Ding, A. A., Chen, Y. Y., Churng-Wang, R. C., Li, P. C., & Shieh, D-B. (2008). HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy. In 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO (pp. 882-885). [4617246] (2008 8th IEEE Conference on Nanotechnology, IEEE-NANO). https://doi.org/10.1109/NANO.2008.264
Ding, Ann Ann ; Chen, Ying Yi ; Churng-Wang, Ren Chris ; Li, Pai Chi ; Shieh, Dar-Bin. / HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy. 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO. 2008. pp. 882-885 (2008 8th IEEE Conference on Nanotechnology, IEEE-NANO).
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abstract = "Recent studies reported gold nano rod (AuNRs) exhibit surface plasmonic resonance frequency (SPR) proportional to their aspect ratio. The interaction of AuNRs with electromagnetic radiation corresponding to their SPR could generate local regional heat. With precise control of the aspect ratio, AuNR could interact with near-infrared (NIR) laser light in the biological optical window that best penetrate human tissues to optimize hyperthermia therapy [1]. We exploit AuNRs to conjugate HER-2 antibodies specific for targeting tumor cells. HER-2 was reported to be associated with disease prognosis and clinical theray [2] and was reported to be over-expressed in many types of cancer. In this study, AuNRs was found to present high bio-compatibility and hemo-compatibility. In vitro laser induced hyperthermia study revealed a selective damage of OECM-1 cancer cells targeted by the AuNR probe. We discovered only the use of AuNR combined correct laser wavelength corresponding to SPR of the AuNR could induce effective hyperthermia therapy. In vivo model using tumor bearing SCID mice, an increase in tumor local temperature and improved therapeutic results were discovered in the AuNRs-HER2 treatment group compared to that of AuNRs alone. In conclusion, HER-2 antibodies conjugated AuNR combined NIR laser could be a potent modality in cancer targeting therapy that could minimize side effects attribute to the nanoscale precision of high temperature delivery. Besides, AuNRs showed a tunable SPR within NIR range could be applied for multiplex photo-thermal effect and combined multiple target photo-acoustic molecular imaging for combined diagnosis and therapy in a single platform.",
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Ding, AA, Chen, YY, Churng-Wang, RC, Li, PC & Shieh, D-B 2008, HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy. in 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO., 4617246, 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO, pp. 882-885, 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO, Arlington, TX, United States, 08-08-18. https://doi.org/10.1109/NANO.2008.264

HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy. / Ding, Ann Ann; Chen, Ying Yi; Churng-Wang, Ren Chris; Li, Pai Chi; Shieh, Dar-Bin.

2008 8th IEEE Conference on Nanotechnology, IEEE-NANO. 2008. p. 882-885 4617246 (2008 8th IEEE Conference on Nanotechnology, IEEE-NANO).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Ding AA, Chen YY, Churng-Wang RC, Li PC, Shieh D-B. HER-2 antibody conjugated gold nano rod particles for in vivo photothermal therapy. In 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO. 2008. p. 882-885. 4617246. (2008 8th IEEE Conference on Nanotechnology, IEEE-NANO). https://doi.org/10.1109/NANO.2008.264