Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice

Hung Ming Wu, Chiung Chun Huang, Shun-hua Chen, Ying Ching Liang, Jing Jane Tsai, Ching Liang Hsieh, Kuei-Sen Hsu

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Herpes simplex virus type 1 (HSV-1) is the major pathogen related to epilepsy. However, little is known about the pathogenesis of HSV-1-associated epilepsy. Here, we report that corneal inoculation of mice with HSV-1 induces acute spontaneous behavioural and electrophysiological seizures and chronically increases hippocampal excitability and seizure susceptibility. In slices from infected mice, the surviving hippocampal CA3 pyramidal neurons exhibited a more depolarizing resting membrane potential concomitant with an increase in membrane input resistance. They also had a lower threshold for generating synchronized bursts and a decrease in the amplitude of afterhyperpolarization (AHP) than did controls. These results suggest that a direct change in the excitability of the hippocampal CA3 neuronal network could play an important role in facilitating the development of acute seizures and subsequent epilepsy.

Original languageEnglish
Pages (from-to)3294-3304
Number of pages11
JournalEuropean Journal of Neuroscience
Volume18
Issue number12
DOIs
Publication statusPublished - 2003 Dec

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Human Herpesvirus 1
Epilepsy
Seizures
Pyramidal Cells
Membrane Potentials
Membranes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Wu, Hung Ming ; Huang, Chiung Chun ; Chen, Shun-hua ; Liang, Ying Ching ; Tsai, Jing Jane ; Hsieh, Ching Liang ; Hsu, Kuei-Sen. / Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice. In: European Journal of Neuroscience. 2003 ; Vol. 18, No. 12. pp. 3294-3304.
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Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice. / Wu, Hung Ming; Huang, Chiung Chun; Chen, Shun-hua; Liang, Ying Ching; Tsai, Jing Jane; Hsieh, Ching Liang; Hsu, Kuei-Sen.

In: European Journal of Neuroscience, Vol. 18, No. 12, 12.2003, p. 3294-3304.

Research output: Contribution to journalArticle

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