Herpes zoster-associated severity and duration of pain, health-related quality of life, and healthcare utilization in TWN: A prospective observational study

Tsen Fang Tsai, Chien An Yao, Hsin Su Yu, Cheng Che Lan, Sheau Chiou Chao, Jen Hung Yang, Kuo Chia Yang, Ching Yu Chen, Ron R. White, Eliofotisti Psaradellis, Emmanouil Rampakakis, Kosuke Kawai, Camilo J. Acosta, John S. Sampalis

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Background: To assess the severity and duration of herpes zoster (HZ)-associated pain (ZAP) and its impact on quality of life (QoL) and healthcare utilization (HCRU) from a patient perspective in routine care in TWN. Methods: A prospective, observational, single-cohort study was conducted in five centers across TWN. Patients were recruited at different time points during their HZ episode and were followed for ≤180 days. ZAP was assessed with the Initial Zoster Impact Questionnaire and the Zoster Brief Pain Inventory, QoL with the EQ-5D, and HCRU with a simple questionnaire. Results: A total of 150 patients were included with a mean age of 64.9 years and mean time since rash onset of 18.8 days. Prodromal pain was experienced by 64.7% of patients, of whom 91.8% reported moderate-to-severe pain. At enrollment, 98.0% of patients experienced ZAP. Mean ± SD worst pain score decreased from 5.95 ± 3.09 at enrollment to 2.65 ± 2.98 at 30 days and 0.28 ± 0.83 at 180 days. Postherpetic neuralgia was observed in 20.7% of patients. Mean ± SD EQ-5D score significantly decreased (P < 0.001) from 0.91 ± 0.16 before rash onset to 0.67 ± 0.18 after rash onset, showing significant QoL deterioration up to 60 days. The impact of HZ on QoL and pain severity was similar across age groups. Significant HCRU was observed including visits to the doctor (83.3% of patients), specialist (30.7%), emergency department (24.7%), physiotherapist (23.3%), and hospitalizations (20.7%). Conclusion: Severe morbidity and significant HCRU are associated with HZ in TWN, supporting the need for early intervention and preventive strategies to reduce the HZ-associated burden of illness.

Original languageEnglish
Pages (from-to)529-536
Number of pages8
JournalInternational Journal of Dermatology
Volume54
Issue number5
DOIs
Publication statusPublished - 2015 May 1

All Science Journal Classification (ASJC) codes

  • Dermatology

Fingerprint Dive into the research topics of 'Herpes zoster-associated severity and duration of pain, health-related quality of life, and healthcare utilization in TWN: A prospective observational study'. Together they form a unique fingerprint.

Cite this