Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis

Aim On Saengsirinavin; Chaw Ning Lee; Negin Yavari; Frances Andrea Anover; Zheng Xian Thng; Jia Horung Hung; Chew Zhi Rui John; Dalia El Feky; Osama Elaraby; Xiaoyan Zhang; Cigdem Yasar; Azadeh Mobasserian; Amir Akhavanrezayat; Ngoc Trong Tuong Than; Christopher Or; Quan Dong Nguyen

doi:10.1016/j.idcr.2025.e02321

Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis

Aim On Saengsirinavin
, Chaw Ning Lee
, Negin Yavari
, Frances Andrea Anover
, Zheng Xian Thng
, Jia Horung Hung
, Chew Zhi Rui John
, Dalia El Feky
, Osama Elaraby
, Xiaoyan Zhang
, Cigdem Yasar
, Azadeh Mobasserian
, Amir Akhavanrezayat
, Ngoc Trong Tuong Than
, Christopher Or
, Quan Dong Nguyen

Research output: Contribution to journal › Article › peer-review

Abstract

We present the case of an 18-year-old male with bilateral idiopathic chorioretinitis maintained on immunosuppressive therapy with prednisone, adalimumab, and mycophenolate mofetil, who developed ulcers and bleeding of the lip mucosa after taking nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanate for a suspected ear infection. The clinical presentation initially mimicked Stevens-Johnson syndrome (SJS), but further evaluation confirmed the diagnosis of herpetic gingivostomatitis. This case highlights the diagnostic challenges in differentiating between drug eruptions and infectious etiologies in immunosuppressed patients. Despite its severity, prompt recognition and antiviral therapy can lead to full recovery.

Original language	English
Article number	e02321
Journal	IDCases
Volume	41
DOIs	https://doi.org/10.1016/j.idcr.2025.e02321
Publication status	Published - 2025 Jan

All Science Journal Classification (ASJC) codes

Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.idcr.2025.e02321

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Saengsirinavin, A. O., Lee, C. N., Yavari, N., Anover, F. A., Thng, Z. X., Hung, J. H., John, C. Z. R., El Feky, D., Elaraby, O., Zhang, X., Yasar, C., Mobasserian, A., Akhavanrezayat, A., Than, N. T. T., Or, C., & Nguyen, Q. D. (2025). Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis. IDCases, 41, Article e02321. https://doi.org/10.1016/j.idcr.2025.e02321

@article{7912a6f2b40d4a2d8012b9e39f090650,

title = "Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis",

abstract = "We present the case of an 18-year-old male with bilateral idiopathic chorioretinitis maintained on immunosuppressive therapy with prednisone, adalimumab, and mycophenolate mofetil, who developed ulcers and bleeding of the lip mucosa after taking nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanate for a suspected ear infection. The clinical presentation initially mimicked Stevens-Johnson syndrome (SJS), but further evaluation confirmed the diagnosis of herpetic gingivostomatitis. This case highlights the diagnostic challenges in differentiating between drug eruptions and infectious etiologies in immunosuppressed patients. Despite its severity, prompt recognition and antiviral therapy can lead to full recovery.",

author = "Saengsirinavin, \{Aim On\} and Lee, \{Chaw Ning\} and Negin Yavari and Anover, \{Frances Andrea\} and Thng, \{Zheng Xian\} and Hung, \{Jia Horung\} and John, \{Chew Zhi Rui\} and \{El Feky\}, Dalia and Osama Elaraby and Xiaoyan Zhang and Cigdem Yasar and Azadeh Mobasserian and Amir Akhavanrezayat and Than, \{Ngoc Trong Tuong\} and Christopher Or and Nguyen, \{Quan Dong\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = jan,

doi = "10.1016/j.idcr.2025.e02321",

language = "English",

volume = "41",

journal = "IDCases",

issn = "2214-2509",

publisher = "Elsevier Limited",

}

Saengsirinavin, AO, Lee, CN, Yavari, N, Anover, FA, Thng, ZX, Hung, JH, John, CZR, El Feky, D, Elaraby, O, Zhang, X, Yasar, C, Mobasserian, A, Akhavanrezayat, A, Than, NTT, Or, C & Nguyen, QD 2025, 'Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis', IDCases, vol. 41, e02321. https://doi.org/10.1016/j.idcr.2025.e02321

TY - JOUR

T1 - Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis

AU - Saengsirinavin, Aim On

AU - Lee, Chaw Ning

AU - Yavari, Negin

AU - Anover, Frances Andrea

AU - Thng, Zheng Xian

AU - Hung, Jia Horung

AU - John, Chew Zhi Rui

AU - El Feky, Dalia

AU - Elaraby, Osama

AU - Zhang, Xiaoyan

AU - Yasar, Cigdem

AU - Mobasserian, Azadeh

AU - Akhavanrezayat, Amir

AU - Than, Ngoc Trong Tuong

AU - Or, Christopher

AU - Nguyen, Quan Dong

PY - 2025/1

Y1 - 2025/1

N2 - We present the case of an 18-year-old male with bilateral idiopathic chorioretinitis maintained on immunosuppressive therapy with prednisone, adalimumab, and mycophenolate mofetil, who developed ulcers and bleeding of the lip mucosa after taking nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanate for a suspected ear infection. The clinical presentation initially mimicked Stevens-Johnson syndrome (SJS), but further evaluation confirmed the diagnosis of herpetic gingivostomatitis. This case highlights the diagnostic challenges in differentiating between drug eruptions and infectious etiologies in immunosuppressed patients. Despite its severity, prompt recognition and antiviral therapy can lead to full recovery.

AB - We present the case of an 18-year-old male with bilateral idiopathic chorioretinitis maintained on immunosuppressive therapy with prednisone, adalimumab, and mycophenolate mofetil, who developed ulcers and bleeding of the lip mucosa after taking nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanate for a suspected ear infection. The clinical presentation initially mimicked Stevens-Johnson syndrome (SJS), but further evaluation confirmed the diagnosis of herpetic gingivostomatitis. This case highlights the diagnostic challenges in differentiating between drug eruptions and infectious etiologies in immunosuppressed patients. Despite its severity, prompt recognition and antiviral therapy can lead to full recovery.

UR - https://www.scopus.com/pages/publications/105010615641

UR - https://www.scopus.com/pages/publications/105010615641#tab=citedBy

U2 - 10.1016/j.idcr.2025.e02321

DO - 10.1016/j.idcr.2025.e02321

M3 - Article

AN - SCOPUS:105010615641

SN - 2214-2509

VL - 41

JO - IDCases

JF - IDCases

M1 - e02321

ER -

Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis

Abstract

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