Hierarchical petri nets for modeling metabolic phenotype in prokaryotes

N. Balasubramanian, Ming Li Yeh, Chuei Tin Chang, Shu Jen Chen

Research output: Contribution to journalArticlepeer-review


A systematic strategy is presented in this paper to build Petri-net models for the biological reaction networks and their gene regulation mechanisms in prokaryotes. Component models are first developed to represent the cellular functional units, i.e., operons, regulons, modulons, and individual reactions. A step-by-step procedure is then proposed to assemble these components to form hierarchical system models. The usefulness of the proposed approach is demonstrated with a realistic example. The model validity is shown by comparing simulation predictions with experimental data in the literature.

Original languageEnglish
Pages (from-to)2218-2240
Number of pages23
JournalIndustrial and Engineering Chemistry Research
Issue number7
Publication statusPublished - 2005 Mar 30

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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