TY - JOUR
T1 - High-fat diet reduces the hippocampal content level of lactate which is correlated with the expression of glial glutamate transporters
AU - Tsai, Sheng Feng
AU - Chen, Yun-Wen
AU - Kuo, Yu Min
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Metabolic disorders hamper the brain metabolism and functions. The astrocytic glucose-derived lactate is known to fill the increased energy needs of neurons during synaptic transmission. However, whether systemic metabolism dysregulation affects the astrocytic lactate metabolism in the brain remain unexamined. To address this question, we adopt a 12-week high-fat diet to induce metabolic disorders in adult mice, and the effects of high-fat diet on the lactate metabolism in the hippocampus were examined. Results showed that a 12-week high-fat diet induced obesity and insulin resistance in mice. High-fat diet also decreased the lactate content levels and the expression of glial glutamate transporters, GLAST and GLT-1, in the hippocampus. Strong correlations between the lactate levels and the levels of GLAST and GLT-1 were evidenced. In conclusion, high-fat feeding induces metabolic disorders and disrupts lactate metabolism in the hippocampus. GLAST and GLT-1 may contribute to the HFD-induced abnormalities of the hippocampal lactate metabolism.
AB - Metabolic disorders hamper the brain metabolism and functions. The astrocytic glucose-derived lactate is known to fill the increased energy needs of neurons during synaptic transmission. However, whether systemic metabolism dysregulation affects the astrocytic lactate metabolism in the brain remain unexamined. To address this question, we adopt a 12-week high-fat diet to induce metabolic disorders in adult mice, and the effects of high-fat diet on the lactate metabolism in the hippocampus were examined. Results showed that a 12-week high-fat diet induced obesity and insulin resistance in mice. High-fat diet also decreased the lactate content levels and the expression of glial glutamate transporters, GLAST and GLT-1, in the hippocampus. Strong correlations between the lactate levels and the levels of GLAST and GLT-1 were evidenced. In conclusion, high-fat feeding induces metabolic disorders and disrupts lactate metabolism in the hippocampus. GLAST and GLT-1 may contribute to the HFD-induced abnormalities of the hippocampal lactate metabolism.
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U2 - 10.1016/j.neulet.2017.10.024
DO - 10.1016/j.neulet.2017.10.024
M3 - Article
C2 - 29051084
AN - SCOPUS:85031492546
SN - 0304-3940
VL - 662
SP - 142
EP - 146
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -