High Frequency Electromagnetic Thermotherapy for Cancer Treatment

Sheng Chieh Huang, Chih Hao Huang, Xi-Zhang Lin, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Background/Aim: Electromagnetic thermotherapy is a new modality for cancer treatment. It applies a highfrequency electrical current to generate a magnetic field and heat up magnetic materials for treating targeted cancers. Using such system, we treat big tumors (more than 1.5 cm in diameter) in a colon cancer bearing murine model. Material and Methods: The high-frequency electromagnetic machine has an input of 220V-55A-60Hz. The output frequency and power are 40 kHz and 20 kW, respectively. The magnetic materials are fine needles made of stainless steel. We used agarose gel and porcine liver for thermo-dosimetry in vitro and ex vivo. During the experiments, IR camera was used to detect the temperature distributions. In an animal model, BALB/C mice were implanted with CT-26 colon cancer cells subcutaneously over their back. After the tumor size grew bigger than 15mm x 15mm, mice were divided into two groups randomly. Group I (n=8) were put in the magnetic field for twenty minutes as a control group. Group II (n=15) were inserted with fine needles into the tumor and magnetic field was used to treat the tumors for twenty minutes. Results: From IR thermography, the needles in a matrix can achieve better temperature distributions in the targeted area than that from a needle alone. In the animal model, the survival rate achieved 90% in the treated group and no residual tumors over their back at the end of observation (60 days); while in the control group, the survival rate on the 45th day was 0%. Conclusion: Our experiments showed that using high frequency electromagnetic thermotherapy is very effective to treat big tumors in the animal model, and our method has great potential for future clinical applications.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages574-577
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08-12-0308-12-06

Fingerprint

Oncology
Tumors
Needles
Animals
Magnetic materials
Magnetic fields
Temperature distribution
Bearings (structural)
Stainless Steel
Liver
Sepharose
Dosimetry
Stainless steel
Gels
Experiments
Cameras
Cells

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Bioengineering

Cite this

Huang, S. C., Huang, C. H., Lin, X-Z., & Lee, G. B. (2009). High Frequency Electromagnetic Thermotherapy for Cancer Treatment. In 13th International Conference on Biomedical Engineering - ICBME 2008 (pp. 574-577). (IFMBE Proceedings; Vol. 23). https://doi.org/10.1007/978-3-540-92841-6_141
Huang, Sheng Chieh ; Huang, Chih Hao ; Lin, Xi-Zhang ; Lee, Gwo Bin. / High Frequency Electromagnetic Thermotherapy for Cancer Treatment. 13th International Conference on Biomedical Engineering - ICBME 2008. 2009. pp. 574-577 (IFMBE Proceedings).
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title = "High Frequency Electromagnetic Thermotherapy for Cancer Treatment",
abstract = "Background/Aim: Electromagnetic thermotherapy is a new modality for cancer treatment. It applies a highfrequency electrical current to generate a magnetic field and heat up magnetic materials for treating targeted cancers. Using such system, we treat big tumors (more than 1.5 cm in diameter) in a colon cancer bearing murine model. Material and Methods: The high-frequency electromagnetic machine has an input of 220V-55A-60Hz. The output frequency and power are 40 kHz and 20 kW, respectively. The magnetic materials are fine needles made of stainless steel. We used agarose gel and porcine liver for thermo-dosimetry in vitro and ex vivo. During the experiments, IR camera was used to detect the temperature distributions. In an animal model, BALB/C mice were implanted with CT-26 colon cancer cells subcutaneously over their back. After the tumor size grew bigger than 15mm x 15mm, mice were divided into two groups randomly. Group I (n=8) were put in the magnetic field for twenty minutes as a control group. Group II (n=15) were inserted with fine needles into the tumor and magnetic field was used to treat the tumors for twenty minutes. Results: From IR thermography, the needles in a matrix can achieve better temperature distributions in the targeted area than that from a needle alone. In the animal model, the survival rate achieved 90{\%} in the treated group and no residual tumors over their back at the end of observation (60 days); while in the control group, the survival rate on the 45th day was 0{\%}. Conclusion: Our experiments showed that using high frequency electromagnetic thermotherapy is very effective to treat big tumors in the animal model, and our method has great potential for future clinical applications.",
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Huang, SC, Huang, CH, Lin, X-Z & Lee, GB 2009, High Frequency Electromagnetic Thermotherapy for Cancer Treatment. in 13th International Conference on Biomedical Engineering - ICBME 2008. IFMBE Proceedings, vol. 23, pp. 574-577, 13th International Conference on Biomedical Engineering, ICBME 2008, Singapore, 08-12-03. https://doi.org/10.1007/978-3-540-92841-6_141

High Frequency Electromagnetic Thermotherapy for Cancer Treatment. / Huang, Sheng Chieh; Huang, Chih Hao; Lin, Xi-Zhang; Lee, Gwo Bin.

13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 574-577 (IFMBE Proceedings; Vol. 23).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Background/Aim: Electromagnetic thermotherapy is a new modality for cancer treatment. It applies a highfrequency electrical current to generate a magnetic field and heat up magnetic materials for treating targeted cancers. Using such system, we treat big tumors (more than 1.5 cm in diameter) in a colon cancer bearing murine model. Material and Methods: The high-frequency electromagnetic machine has an input of 220V-55A-60Hz. The output frequency and power are 40 kHz and 20 kW, respectively. The magnetic materials are fine needles made of stainless steel. We used agarose gel and porcine liver for thermo-dosimetry in vitro and ex vivo. During the experiments, IR camera was used to detect the temperature distributions. In an animal model, BALB/C mice were implanted with CT-26 colon cancer cells subcutaneously over their back. After the tumor size grew bigger than 15mm x 15mm, mice were divided into two groups randomly. Group I (n=8) were put in the magnetic field for twenty minutes as a control group. Group II (n=15) were inserted with fine needles into the tumor and magnetic field was used to treat the tumors for twenty minutes. Results: From IR thermography, the needles in a matrix can achieve better temperature distributions in the targeted area than that from a needle alone. In the animal model, the survival rate achieved 90% in the treated group and no residual tumors over their back at the end of observation (60 days); while in the control group, the survival rate on the 45th day was 0%. Conclusion: Our experiments showed that using high frequency electromagnetic thermotherapy is very effective to treat big tumors in the animal model, and our method has great potential for future clinical applications.

AB - Background/Aim: Electromagnetic thermotherapy is a new modality for cancer treatment. It applies a highfrequency electrical current to generate a magnetic field and heat up magnetic materials for treating targeted cancers. Using such system, we treat big tumors (more than 1.5 cm in diameter) in a colon cancer bearing murine model. Material and Methods: The high-frequency electromagnetic machine has an input of 220V-55A-60Hz. The output frequency and power are 40 kHz and 20 kW, respectively. The magnetic materials are fine needles made of stainless steel. We used agarose gel and porcine liver for thermo-dosimetry in vitro and ex vivo. During the experiments, IR camera was used to detect the temperature distributions. In an animal model, BALB/C mice were implanted with CT-26 colon cancer cells subcutaneously over their back. After the tumor size grew bigger than 15mm x 15mm, mice were divided into two groups randomly. Group I (n=8) were put in the magnetic field for twenty minutes as a control group. Group II (n=15) were inserted with fine needles into the tumor and magnetic field was used to treat the tumors for twenty minutes. Results: From IR thermography, the needles in a matrix can achieve better temperature distributions in the targeted area than that from a needle alone. In the animal model, the survival rate achieved 90% in the treated group and no residual tumors over their back at the end of observation (60 days); while in the control group, the survival rate on the 45th day was 0%. Conclusion: Our experiments showed that using high frequency electromagnetic thermotherapy is very effective to treat big tumors in the animal model, and our method has great potential for future clinical applications.

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Huang SC, Huang CH, Lin X-Z, Lee GB. High Frequency Electromagnetic Thermotherapy for Cancer Treatment. In 13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 574-577. (IFMBE Proceedings). https://doi.org/10.1007/978-3-540-92841-6_141