High-Incidence of Human Adenoviral Co-Infections in Taiwan

Shan Li Wang, Chia Yu Chi, Pin Hwa Kuo, Huey Pin Tsai, Shih Min Wang, Ching Chuan Liu, Ih Jen Su, Jen Ren Wang

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20 Citations (Scopus)


Background:Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.Study Design:One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.Results:HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.Conclusions:HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.

Original languageEnglish
Article numbere75208
JournalPloS one
Issue number9
Publication statusPublished - 2013 Sep 20

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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