Abstract
Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.
| Original language | English |
|---|---|
| Pages (from-to) | 102-106 |
| Number of pages | 5 |
| Journal | Bipolar Disorders |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 Feb 1 |
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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Chang, T. T., Yeh, T. L., Chiu, N. T., Chen, P. S., Huang, H. Y., Yang, Y. K., Lee, I. H., & Lu, R. B. (2010). Higher striatal dopamine transporters in euthymic patients with bipolar disorder: A SPECT study with [99mTc] TRODAT-1. Bipolar Disorders, 12(1), 102-106. https://doi.org/10.1111/j.1399-5618.2009.00771.x