Higher striatal dopamine transporters in euthymic patients with bipolar disorder: A SPECT study with [99mTc] TRODAT-1

Ting Ting Chang, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Hsiang Yu Huang, Yen Kuang Yang, I. Hui Lee, Ru Band Lu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalBipolar Disorders
Volume12
Issue number1
DOIs
Publication statusPublished - 2010 Feb 1

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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