Higher striatal dopamine transporters in euthymic patients with bipolar disorder: A SPECT study with [99mTc] TRODAT-1

Ting Ting Chang; Tzung Lieh Yeh; Nan Tsing Chiu; Po See Chen; Hsiang Yu Huang; Yen Kuang Yang; I. Hui Lee; Ru Band Lu

doi:10.1111/j.1399-5618.2009.00771.x

Higher striatal dopamine transporters in euthymic patients with bipolar disorder: A SPECT study with [^99mTc] TRODAT-1

Ting Ting Chang, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Hsiang Yu Huang, Yen Kuang Yang, I. Hui Lee, Ru Band Lu

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [^99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.

Original language	English
Pages (from-to)	102-106
Number of pages	5
Journal	Bipolar Disorders
Volume	12
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-5618.2009.00771.x
Publication status	Published - 2010 Feb

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1111/j.1399-5618.2009.00771.x

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title = "Higher striatal dopamine transporters in euthymic patients with bipolar disorder: A SPECT study with [99mTc] TRODAT-1",

abstract = "Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.",

author = "Chang, {Ting Ting} and Yeh, {Tzung Lieh} and Chiu, {Nan Tsing} and Chen, {Po See} and Huang, {Hsiang Yu} and Yang, {Yen Kuang} and Lee, {I. Hui} and Lu, {Ru Band}",

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doi = "10.1111/j.1399-5618.2009.00771.x",

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T1 - Higher striatal dopamine transporters in euthymic patients with bipolar disorder

T2 - A SPECT study with [99mTc] TRODAT-1

AU - Chang, Ting Ting

AU - Yeh, Tzung Lieh

AU - Chiu, Nan Tsing

AU - Chen, Po See

AU - Huang, Hsiang Yu

AU - Yang, Yen Kuang

AU - Lee, I. Hui

AU - Lu, Ru Band

PY - 2010/2

Y1 - 2010/2

N2 - Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.

AB - Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.

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Higher striatal dopamine transporters in euthymic patients with bipolar disorder: A SPECT study with [^99mTc] TRODAT-1

Abstract

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