Hippocampal noradrenergic neurotransmission in concurrent EEG desynchronization and inhibition of penile erection induced by cocaine in the rat

Ya-Wen Zhang, Julie Y.H. Chan, Samuel H.H. Chan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. We previously reported that cocaine may induce activation of cortical (cEEG) and hippocampal (hEEG) electroencephalographic signals, concurrent with inhibition of penile erection, via an action on the hippocampal formation. The present study further evaluates the role of noradrenergic neurotransmission at the hippocampal formation in this process, using adult, male Sprague-Dawley rats anaesthetized and maintained by chloral hydrate. 2. Unilateral microinjection of cocaine (100 nmoles) into the hippocampal CA1 or CA3 subfield or dentate gyrus elicited significant activation of both cEEG and hEEG activity. At the same time, the intracavernous pressure (ICP), our experimental index for penile erection, underwent a discernible reduction. 3. Co-administration of equimolar doses (250 pmoles) of prazosin, naftopidil, yohimbine or rauwolscine significantly reversed those effects elicited by cocaine on cEEG, hEEG and TCP. 4. Microinjection unilaterally of equimolar doses (5 nmoles) of norepinephrine, phenylephrine or BHT 933 into the hippocampal formation, similar to cocaine, also induced appreciable cEEG and hEEG excitation, with a simultaneous decrease in TCP. 5. We conclude that cocaine may activate cEEG and hEEG and decrease TCP, in noradrenergic neurotransmission, possibly engaging at least α(1A/D)-, α(2B)-, and α(2C)-adrenoceptors at the hippocampal formation.

Original languageEnglish
Pages (from-to)1553-1560
Number of pages8
JournalBritish Journal of Pharmacology
Volume130
Issue number7
DOIs
Publication statusPublished - 2000 Jan 1

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Penile Erection
Cocaine
Synaptic Transmission
Electroencephalography
Hippocampus
Yohimbine
Microinjections
Chloral Hydrate
Prazosin
Dentate Gyrus
Phenylephrine
Adrenergic Receptors
Sprague Dawley Rats
Norepinephrine
Pressure

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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abstract = "1. We previously reported that cocaine may induce activation of cortical (cEEG) and hippocampal (hEEG) electroencephalographic signals, concurrent with inhibition of penile erection, via an action on the hippocampal formation. The present study further evaluates the role of noradrenergic neurotransmission at the hippocampal formation in this process, using adult, male Sprague-Dawley rats anaesthetized and maintained by chloral hydrate. 2. Unilateral microinjection of cocaine (100 nmoles) into the hippocampal CA1 or CA3 subfield or dentate gyrus elicited significant activation of both cEEG and hEEG activity. At the same time, the intracavernous pressure (ICP), our experimental index for penile erection, underwent a discernible reduction. 3. Co-administration of equimolar doses (250 pmoles) of prazosin, naftopidil, yohimbine or rauwolscine significantly reversed those effects elicited by cocaine on cEEG, hEEG and TCP. 4. Microinjection unilaterally of equimolar doses (5 nmoles) of norepinephrine, phenylephrine or BHT 933 into the hippocampal formation, similar to cocaine, also induced appreciable cEEG and hEEG excitation, with a simultaneous decrease in TCP. 5. We conclude that cocaine may activate cEEG and hEEG and decrease TCP, in noradrenergic neurotransmission, possibly engaging at least α(1A/D)-, α(2B)-, and α(2C)-adrenoceptors at the hippocampal formation.",
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Hippocampal noradrenergic neurotransmission in concurrent EEG desynchronization and inhibition of penile erection induced by cocaine in the rat. / Zhang, Ya-Wen; Chan, Julie Y.H.; Chan, Samuel H.H.

In: British Journal of Pharmacology, Vol. 130, No. 7, 01.01.2000, p. 1553-1560.

Research output: Contribution to journalArticle

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