Histology impacts the outcome of peripheral T-cell lymphomas after high dose chemotherapy and stem cell transplant

Madan Jagasia, David Morgan, Stacey Goodman, Katherine Hamilton, Marsha Kinney, Yu Shyr, Richard Stein, John Zic, John Greer

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Abstract

The role of high dose chemotherapy (HDC) and stem cell transplant (SCT) in peripheral T-cell lymphoma (PTCL) was studied in 28 patients, from 1988 to 2002. The aim was to determine if subsets recognized by the REAL/WHO classification have different prognoses. Outcome was compared to 86 patients with diffuse large B-cell lymphoma (DLBCL) transplanted during 1986-2000. The 3-year overall survival (OS) and event free survival (EFS) were 69% and 50%. Patients with anaplastic large cell lymphoma (ALCL) had a better 3-year OS compared to those with non-ALCL histology (86% vs. 47%, P = 0.0122). Anaplastic lymphoma kinase (ALK)- positive ALCL patients had a superior EFS compared to ALK-negative ALCL (100% vs. 0; P = 0.0228). Patients with cutaneous ALCL (ALK- negative) relapsed, but had an indolent course after SCT. Low International Prognostic Index score at relapse predicted for a better 3-year OS (85% vs. 34%, P = 0.0238). When compared to DLBCL, patients with ALCL had a superior OS (86% vs. 36%, P = 0.0034) and patients with non-ALCL had a comparable OS. ALCL histology confers better survival compared to non-ALCL and DLBCL histologies. ALK-positive ALCL is associated with the best EFS after relapse with HDC and SCT. The timing of SCT for non-ALCL histology remains to be determined.

Original languageEnglish
Pages (from-to)2261-2267
Number of pages7
JournalLeukemia and Lymphoma
Volume45
Issue number11
DOIs
Publication statusPublished - 2004 Nov 1

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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    Jagasia, M., Morgan, D., Goodman, S., Hamilton, K., Kinney, M., Shyr, Y., Stein, R., Zic, J., & Greer, J. (2004). Histology impacts the outcome of peripheral T-cell lymphomas after high dose chemotherapy and stem cell transplant. Leukemia and Lymphoma, 45(11), 2261-2267. https://doi.org/10.1080/10428190412331272749