Histone deacetylase complexes: Functional entities or molecular reservoirs

Saadi Khochbin, Hung Ying Kao

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Recent investigations have allowed the identification of an increasing number of distinct nuclear multi-component complexes containing several types of enzymatic activity. Many of the complexes containing histone deacetylases are believed to control transcription and chromatin remodeling. We suggest here that at least some of these abundant complexes are likely to be 'molecular reservoirs' of dynamic composition that exchange factors with other less abundant and functional complexes, according to specific required activities.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalFEBS Letters
Volume494
Issue number3
DOIs
Publication statusPublished - 2001 Apr 13

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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