Hollow mesoporous silica nanosphere-supported FePt nanoparticles for potential theranostic applications

Chih Yu Lin, Wei Peng Li, Shao Peng Huang, Chen Sheng Yeh, Chia Min Yang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A facile preparation of a nanocomposite comprising FePt nanoparticles (NPs) and hollow mesoporous silica nanospheres (HMSNs) was reported. The bimetallic NPs had an alloy structure with Pt-rich cores and were highly dispersed on the mesoporous shell of HMSNs. The material, designated as FePt@MMT-2, could be gradually degraded and dissolved under physiological conditions and showed low cytotoxicity against HeLa cells. FePt@MMT-2 exhibited ferromagnetic-like properties and broadband near-infrared (NIR) absorption along with high photothermal transduction efficiency. In addition, in vitro studies showed high efficacy of FePt@MMT-2 in killing HeLa cells with 1064 nm NIR irradiation, and synergistic anticancer effects when combined with chemo drug topotecan. The results demonstrated the potential of the designed nanocomposite for theranostic applications.

Original languageEnglish
Pages (from-to)7598-7607
Number of pages10
JournalJournal of Materials Chemistry B
Volume5
Issue number36
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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