Hollow mesoporous silica nanosphere-supported FePt nanoparticles for potential theranostic applications

Chih Yu Lin; Wei Peng Li; Shao Peng Huang; Chen Sheng Yeh; Chia Min Yang

doi:10.1039/c7tb01812f

Hollow mesoporous silica nanosphere-supported FePt nanoparticles for potential theranostic applications

Chih Yu Lin, Wei Peng Li, Shao Peng Huang, Chen Sheng Yeh, Chia Min Yang

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A facile preparation of a nanocomposite comprising FePt nanoparticles (NPs) and hollow mesoporous silica nanospheres (HMSNs) was reported. The bimetallic NPs had an alloy structure with Pt-rich cores and were highly dispersed on the mesoporous shell of HMSNs. The material, designated as FePt@MMT-2, could be gradually degraded and dissolved under physiological conditions and showed low cytotoxicity against HeLa cells. FePt@MMT-2 exhibited ferromagnetic-like properties and broadband near-infrared (NIR) absorption along with high photothermal transduction efficiency. In addition, in vitro studies showed high efficacy of FePt@MMT-2 in killing HeLa cells with 1064 nm NIR irradiation, and synergistic anticancer effects when combined with chemo drug topotecan. The results demonstrated the potential of the designed nanocomposite for theranostic applications.

Original language	English
Pages (from-to)	7598-7607
Number of pages	10
Journal	Journal of Materials Chemistry B
Volume	5
Issue number	36
DOIs	https://doi.org/10.1039/c7tb01812f
Publication status	Published - 2017

All Science Journal Classification (ASJC) codes

General Chemistry
Biomedical Engineering
General Materials Science

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10.1039/c7tb01812f

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title = "Hollow mesoporous silica nanosphere-supported FePt nanoparticles for potential theranostic applications",

abstract = "A facile preparation of a nanocomposite comprising FePt nanoparticles (NPs) and hollow mesoporous silica nanospheres (HMSNs) was reported. The bimetallic NPs had an alloy structure with Pt-rich cores and were highly dispersed on the mesoporous shell of HMSNs. The material, designated as FePt@MMT-2, could be gradually degraded and dissolved under physiological conditions and showed low cytotoxicity against HeLa cells. FePt@MMT-2 exhibited ferromagnetic-like properties and broadband near-infrared (NIR) absorption along with high photothermal transduction efficiency. In addition, in vitro studies showed high efficacy of FePt@MMT-2 in killing HeLa cells with 1064 nm NIR irradiation, and synergistic anticancer effects when combined with chemo drug topotecan. The results demonstrated the potential of the designed nanocomposite for theranostic applications.",

author = "Lin, {Chih Yu} and Li, {Wei Peng} and Huang, {Shao Peng} and Yeh, {Chen Sheng} and Yang, {Chia Min}",

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AU - Lin, Chih Yu

AU - Li, Wei Peng

AU - Huang, Shao Peng

AU - Yeh, Chen Sheng

AU - Yang, Chia Min

PY - 2017

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N2 - A facile preparation of a nanocomposite comprising FePt nanoparticles (NPs) and hollow mesoporous silica nanospheres (HMSNs) was reported. The bimetallic NPs had an alloy structure with Pt-rich cores and were highly dispersed on the mesoporous shell of HMSNs. The material, designated as FePt@MMT-2, could be gradually degraded and dissolved under physiological conditions and showed low cytotoxicity against HeLa cells. FePt@MMT-2 exhibited ferromagnetic-like properties and broadband near-infrared (NIR) absorption along with high photothermal transduction efficiency. In addition, in vitro studies showed high efficacy of FePt@MMT-2 in killing HeLa cells with 1064 nm NIR irradiation, and synergistic anticancer effects when combined with chemo drug topotecan. The results demonstrated the potential of the designed nanocomposite for theranostic applications.

AB - A facile preparation of a nanocomposite comprising FePt nanoparticles (NPs) and hollow mesoporous silica nanospheres (HMSNs) was reported. The bimetallic NPs had an alloy structure with Pt-rich cores and were highly dispersed on the mesoporous shell of HMSNs. The material, designated as FePt@MMT-2, could be gradually degraded and dissolved under physiological conditions and showed low cytotoxicity against HeLa cells. FePt@MMT-2 exhibited ferromagnetic-like properties and broadband near-infrared (NIR) absorption along with high photothermal transduction efficiency. In addition, in vitro studies showed high efficacy of FePt@MMT-2 in killing HeLa cells with 1064 nm NIR irradiation, and synergistic anticancer effects when combined with chemo drug topotecan. The results demonstrated the potential of the designed nanocomposite for theranostic applications.

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Hollow mesoporous silica nanosphere-supported FePt nanoparticles for potential theranostic applications

Abstract

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