Human herpesvirus 8-associated lymphoma mimicking cutaneous anaplastic large T-cell lymphoma in a patient with human immunodeficiency virus infection

Meng Fang Li, Cheng Hsiang Hsiao, Yi Lin Chen, Wen-Ya Huang, Yi Hsuan Lee, Hsien Neng Huang, Huang Chun Lien

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Abstract

Primary effusion lymphoma, a human herpesvirus 8 (HHV8)-associated lymphoma, is uncommon, and it is usually seen in human immunodeficiency virus (HIV)-infected patients. It presents as a body cavity-based lymphomatous effusion, but several cases of the so-called solid primary effusion lymphoma presenting as solid tumors without associated lymphomatous effusion have been reported. They have similar clinical, histopathological and immunophenotypical features. Most of them have a B-cell genotype. This suggests the solid variant may represent a clinicopathological spectrum of primary effusion lymphoma. We report a case of HHV8-associated lymphoma histopathologically and immunophenotypically mimicking cutaneous anaplastic large cell lymphoma. The patient was a 31-year-old HIV-seropositive man presenting with skin nodules over his right thigh. Biopsy of the nodules showed anaplastic large cells infiltrating the dermis. These malignant cells strongly expressed CD3, CD30 and CD43. Cutaneous anaplastic large T-cell lymphoma was initially diagnosed, but further tests, including immunoreactivity for HHV8 protein and clonal rearrangements of immunoglobulin genes, confirmed the diagnosis of HHV8-associated B-cell lymphoma with aberrant T-cell marker expression. This case provides an example of solid primary effusion lymphoma mimicking cutaneous anaplastic large T-cell lymphoma and highlights the importance of HHV8 immunohistochemistry and molecular tests in the diagnosis of HHV8-associated lymphoma with a cutaneous presentation.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalJournal of Cutaneous Pathology
Volume39
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

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Anaplastic Large-Cell Lymphoma
Human Herpesvirus 8
T-Cell Lymphoma
Virus Diseases
Primary Effusion Lymphoma
Lymphoma
HIV
Skin
Immunoglobulin Genes
B-Cell Lymphoma
Dermis
Thigh
B-Lymphocytes
Immunohistochemistry
Genotype
T-Lymphocytes
Biopsy
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Li, Meng Fang ; Hsiao, Cheng Hsiang ; Chen, Yi Lin ; Huang, Wen-Ya ; Lee, Yi Hsuan ; Huang, Hsien Neng ; Lien, Huang Chun. / Human herpesvirus 8-associated lymphoma mimicking cutaneous anaplastic large T-cell lymphoma in a patient with human immunodeficiency virus infection. In: Journal of Cutaneous Pathology. 2012 ; Vol. 39, No. 2. pp. 274-278.
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Human herpesvirus 8-associated lymphoma mimicking cutaneous anaplastic large T-cell lymphoma in a patient with human immunodeficiency virus infection. / Li, Meng Fang; Hsiao, Cheng Hsiang; Chen, Yi Lin; Huang, Wen-Ya; Lee, Yi Hsuan; Huang, Hsien Neng; Lien, Huang Chun.

In: Journal of Cutaneous Pathology, Vol. 39, No. 2, 01.02.2012, p. 274-278.

Research output: Contribution to journalArticle

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