Human herpesvirus type 8 in patients with cirrhosis

Correlation with sex, alcoholism, hepatitis B virus, disease severity, and thrombocytopenia

An Liang Chou, Wen-Wei Huang, Shih Ming Tsao, Chi Tsung Li, Cheng Chuan Su

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Immunologic abnormalities in patients with cirrhosis strongly correlate with severity of liver cirrhosis. The association between cirrhosis and human herpesvirus type 8 (HHV-8) infection is unclear. Plasma samples were obtained from 74 healthy control subjects and 59 patients with cirrhosis. The seropositive rates for HHV-8 antibodies in patients with cirrhosis (25/59 [42%]) were significantly higher than that in healthy control subjects (18/74 [24%]; P = .027), particularly in men (P = .027), patients with alcohol-related cirrhosis (P = .032), and patients with thrombocytopenia (P = .019) or Child-Pugh class C cirrhosis (P = .018) or both (P = .015), or hepatitis B virus (HBV) infection (P = .003). Antibody titers in seropositive patients also significantly exceeded those in healthy control subjects (P = .008). All subjects were negative for anti-HIV. In Taiwan, cirrhosis is associated with HHV-8 infection, particularly in men, patients with Child-Pugh class C cirrhosis and/ or thrombocytopenia, and patients with alcohol- or HBV-related cirrhosis.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume130
Issue number2
DOIs
Publication statusPublished - 2008 Aug 1

Fingerprint

Human Herpesvirus 8
Virus Diseases
Hepatitis B virus
Thrombocytopenia
Alcoholism
Fibrosis
Herpesviridae Infections
Healthy Volunteers
Alcohols
Antibodies
Taiwan
Liver Cirrhosis
HIV

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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title = "Human herpesvirus type 8 in patients with cirrhosis: Correlation with sex, alcoholism, hepatitis B virus, disease severity, and thrombocytopenia",
abstract = "Immunologic abnormalities in patients with cirrhosis strongly correlate with severity of liver cirrhosis. The association between cirrhosis and human herpesvirus type 8 (HHV-8) infection is unclear. Plasma samples were obtained from 74 healthy control subjects and 59 patients with cirrhosis. The seropositive rates for HHV-8 antibodies in patients with cirrhosis (25/59 [42{\%}]) were significantly higher than that in healthy control subjects (18/74 [24{\%}]; P = .027), particularly in men (P = .027), patients with alcohol-related cirrhosis (P = .032), and patients with thrombocytopenia (P = .019) or Child-Pugh class C cirrhosis (P = .018) or both (P = .015), or hepatitis B virus (HBV) infection (P = .003). Antibody titers in seropositive patients also significantly exceeded those in healthy control subjects (P = .008). All subjects were negative for anti-HIV. In Taiwan, cirrhosis is associated with HHV-8 infection, particularly in men, patients with Child-Pugh class C cirrhosis and/ or thrombocytopenia, and patients with alcohol- or HBV-related cirrhosis.",
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Human herpesvirus type 8 in patients with cirrhosis : Correlation with sex, alcoholism, hepatitis B virus, disease severity, and thrombocytopenia. / Chou, An Liang; Huang, Wen-Wei; Tsao, Shih Ming; Li, Chi Tsung; Su, Cheng Chuan.

In: American Journal of Clinical Pathology, Vol. 130, No. 2, 01.08.2008, p. 231-237.

Research output: Contribution to journalArticle

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