TY - JOUR
T1 - Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy
AU - Chang, Wun Shaing W.
AU - Chou, Ruey Hwang
AU - Wu, Cheng Wen
AU - Chang, Jang Yang
N1 - Funding Information:
This article was supported by the National Health Research Institutes (grant numbers CA-095-PP-36 & CA-096-PP-27), Department of Health (grant number DOH95-TD-G-111-014) and National Science Council (grant numbers NSC93-3112-P-001-045 & NSC94-2752-B-007-004), Taipei, Taiwan. The authors are grateful to H-R Wu, H-F Yang, C-Y Yuan and S-C Lin for their generous help and assistance.
PY - 2007/10
Y1 - 2007/10
N2 - The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.
AB - The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.
UR - http://www.scopus.com/inward/record.url?scp=36148991024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36148991024&partnerID=8YFLogxK
U2 - 10.1517/13543776.17.10.1227
DO - 10.1517/13543776.17.10.1227
M3 - Review article
AN - SCOPUS:36148991024
VL - 17
SP - 1227
EP - 1240
JO - Expert Opinion on Therapeutic Patents
JF - Expert Opinion on Therapeutic Patents
SN - 1354-3776
IS - 10
ER -