Abstract
The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.
| Original language | English |
|---|---|
| Pages (from-to) | 1227-1240 |
| Number of pages | 14 |
| Journal | Expert Opinion on Therapeutic Patents |
| Volume | 17 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2007 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
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Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy. / Chang, Wun Shaing W.; Chou, Ruey Hwang; Wu, Cheng Wen; Chang, Jang-Yang.
In: Expert Opinion on Therapeutic Patents, Vol. 17, No. 10, 01.10.2007, p. 1227-1240.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy
AU - Chang, Wun Shaing W.
AU - Chou, Ruey Hwang
AU - Wu, Cheng Wen
AU - Chang, Jang-Yang
PY - 2007/10/1
Y1 - 2007/10/1
N2 - The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.
AB - The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.
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UR - http://www.scopus.com/inward/citedby.url?scp=36148991024&partnerID=8YFLogxK
U2 - 10.1517/13543776.17.10.1227
DO - 10.1517/13543776.17.10.1227
M3 - Review article
VL - 17
SP - 1227
EP - 1240
JO - Expert Opinion on Therapeutic Patents
JF - Expert Opinion on Therapeutic Patents
SN - 1354-3776
IS - 10
ER -