Hyaluronic acid-complement interactions-II. Role of divalent cations and gelatin

Chang Nan-Shan, Robert J. Boackle

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Native hyaluronic acid (HA) is reported to be a weak anticomplementary agent. However, the normal buffer systems used for complement tests incorporate gelatin, Ca2+ and Mg2+, which may bind to HA, influence its conformation and interfere with its anticomplementary reactions with complement components such as Cl. In this study, metal ions (Ca2+ and Mg2+), gelatin and fibronectin appeared to react with native HA preparations and block their anticomplementary effects on Cl. In previous studies, we obtained evidence for a relationship between reversible heat-induced HA conformational changes and a subsequent reversible increase in anticomplementary activity. The anticomplementary activity of heat-treated HA preparations was also reduced by gelatin.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalMolecular Immunology
Issue number8
Publication statusPublished - 1985 Aug

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology


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