Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

Fei Wang, Weiwei Gao, Soracha Thamphiwatana, Brian T. Luk, Pavimol Angsantikul, Qiangzhe Zhang, Che Ming J. Hu, Ronnie H. Fang, Jonathan A. Copp, Dissaya Pornpattananangkul, Weiyue Lu, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.

Original languageEnglish
Pages (from-to)3437-3443
Number of pages7
JournalAdvanced Materials
Volume27
Issue number22
DOIs
Publication statusPublished - 2015 Jun 1

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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