Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

Fei Wang; Weiwei Gao; Soracha Thamphiwatana; Brian T. Luk; Pavimol Angsantikul; Qiangzhe Zhang; Che Ming J. Hu; Ronnie H. Fang; Jonathan A. Copp; Dissaya Pornpattananangkul; Weiyue Lu; Liangfang Zhang

doi:10.1002/adma.201501071

Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

Fei Wang
, Weiwei Gao
, Soracha Thamphiwatana
, Brian T. Luk
, Pavimol Angsantikul
, Qiangzhe Zhang
, Che Ming J. Hu
, Ronnie H. Fang
, Jonathan A. Copp
, Dissaya Pornpattananangkul
, Weiyue Lu
, Liangfang Zhang

Center of Applied Nanomedicine

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.

Original language	English
Pages (from-to)	3437-3443
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	22
DOIs	https://doi.org/10.1002/adma.201501071
Publication status	Published - 2015 Jun 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201501071

Cite this

Wang, F., Gao, W., Thamphiwatana, S., Luk, B. T., Angsantikul, P., Zhang, Q., Hu, C. M. J., Fang, R. H., Copp, J. A., Pornpattananangkul, D., Lu, W., & Zhang, L. (2015). Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection. Advanced Materials, 27(22), 3437-3443. https://doi.org/10.1002/adma.201501071

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title = "Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection",

abstract = "A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.",

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year = "2015",

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doi = "10.1002/adma.201501071",

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AU - Wang, Fei

AU - Gao, Weiwei

AU - Thamphiwatana, Soracha

AU - Luk, Brian T.

AU - Angsantikul, Pavimol

AU - Zhang, Qiangzhe

AU - Hu, Che Ming J.

AU - Fang, Ronnie H.

AU - Copp, Jonathan A.

AU - Pornpattananangkul, Dissaya

AU - Lu, Weiyue

AU - Zhang, Liangfang

PY - 2015/6/1

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AB - A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge-hydrogel hybrid show markedly reduced MRSA skin lesion development.

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JF - Advanced Materials

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ER -

Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection

Abstract

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