The mechanism of methanol catalytic partial oxidation (CPO) was studied over copper and platinum catalysts. Cu/ZnO and Pt/ZrO2 catalysts gave different results in methanol CPO, with Cu/ZnO producing more CO2 and Pt/ZrO2 producing more CO. Methanol catalytic partial oxidation seemed to proceed by two main pathways. The first occurred when oxygen was present, as methanol was converted to CO, CO2, H2O, and H2. When oxygen was consumed, the second pathway, methanol decomposition, dominated. This is an abstract of a paper presented at the AIChE Annual Meeting (San Francisco, CA 11/12-17/2006).