Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles

Hao Yu Tseng, Chen Yi Lee, Ying Hsia Shih, Xi Zhang Lin, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a temperature increase on tumor cells by using a commercially-available radiography solution containing superparamagnetic nanoparticles. The biocompatible and biodegradable materials allow us to explore hyperthermia cancer therapy in vivo or in vitro. Experimental data showed that a temperature as high as 72.4°C can be successfully generated for in vitro experiments. In-vitro testing showed that survival rate of the tumor cells can be greatly reduced. In-vivo experiments showed that the hyperthermia therapy can significantly repress the growth of liver tumors by utilizing concentrated commercial nanoparticles and temperature-sensitive hydrogel. Hydrogel used in drug delivery system was liquid at low temperature (<20°C) and became gel above 30°C. The gel can be used to secure the nanoparticles in the target tumor tissue. Furthermore, a temperature control system was designed to keep the nanoparticles at a constant temperature such that a reliable cancer therapy can be feasible.

Original languageEnglish
Title of host publicationProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages163-166
Number of pages4
DOIs
Publication statusPublished - 2007 Aug 28
Event2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand
Duration: 2007 Jan 162007 Jan 19

Publication series

NameProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Other

Other2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
CountryThailand
CityBangkok
Period07-01-1607-01-19

Fingerprint

Tumors
Nanoparticles
Hydrogels
Gels
Hyperthermia therapy
Temperature
Cells
Radiography
Temperature control
Liver
Experiments
Tissue
Magnetic fields
Control systems
Liquids
Testing

All Science Journal Classification (ASJC) codes

  • Computer Networks and Communications
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this

Tseng, H. Y., Lee, C. Y., Shih, Y. H., Lin, X. Z., & Lee, G. B. (2007). Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 163-166). [4160556] (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352253
Tseng, Hao Yu ; Lee, Chen Yi ; Shih, Ying Hsia ; Lin, Xi Zhang ; Lee, Gwo Bin. / Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. pp. 163-166 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).
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Tseng, HY, Lee, CY, Shih, YH, Lin, XZ & Lee, GB 2007, Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. in Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007., 4160556, Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, pp. 163-166, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, Bangkok, Thailand, 07-01-16. https://doi.org/10.1109/NEMS.2007.352253

Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. / Tseng, Hao Yu; Lee, Chen Yi; Shih, Ying Hsia; Lin, Xi Zhang; Lee, Gwo Bin.

Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 163-166 4160556 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Tseng HY, Lee CY, Shih YH, Lin XZ, Lee GB. Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 163-166. 4160556. (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352253