Hypoglycemic diterpenoids from Tinospora crispa

Sio Hong Lam, Chi Tun Ruan, Po Hung Hsieh, Ming Jai Su, Shoei Sheng Lee

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Three new diterpenoids, 2-O-lactoylborapetoside B (1), 6′-O- lactoylborapetoside B (2), and tinocrispol A (3), and nine known diterpenoids (4-12) were isolated from an EtOH extract of Tinospora crispa vines. Their structures were elucidated by spectroscopic analyses. The C-6 glucosyloxy group in borapetoside C (6) was revised to be α-oriented. The in vivo hypoglycemic activities of the major components, borapetosides A-C (4-6), were examined. Intraperitoneal injection of 4 and 6 (5 mg/kg) showed significant lowering of plasma glucose levels in normal and streptozotocin-induced type 1 diabetic mice. Borapetoside C increased glucose utilization in peripheral tissues and reduced hepatic gluconeogenesis, accounting for the hypoglycemic effect.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalJournal of Natural Products
Volume75
Issue number2
DOIs
Publication statusPublished - 2012 Feb 24

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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